Description

L-5-Methyltetrahydrofolic Acid Powder

L-5-Methyltetrahydrofolic acid (L-5-MTHF) is the biologically active, naturally occurring form of folate. Unlike folic acid, the synthetic form commonly used in supplements, L-5-MTHF does not require enzymatic conversion in the body to become biologically active. It is the predominant form of folate found in the bloodstream and is directly utilized in critical metabolic processes, including the methylation of homocysteine to methionine, a pathway essential for cardiovascular health and normal cellular function.

🧬 The "Bioactive Folate": The majority of the population possesses genetic variations (such as MTHFR polymorphisms) that limit their ability to convert folic acid into its active L-5-MTHF form. Supplementing directly with L-5-MTHF bypasses this conversion bottleneck, making it a superior choice for individuals seeking optimal folate status, particularly during pregnancy and for those with MTHFR enzyme limitations.

Superior Stability & Bioavailability: L-5-MTHF is stabilized as a calcium salt, offering improved shelf-life and storage stability compared to other forms of active folate. It is the key ingredient in advanced dietary supplements and functional foods, offering a clean-label alternative to folic acid.

🌡️ Storage Note: L-5-MTHF is sensitive to light, oxygen, and heat. Store in the original sealed container, protected from light, under cool, dry conditions. For long-term stability, store at -20°C.

Specification: ≥98.0% – 99.0% (HPLC, on dried basis)
Sample: Sample Available
Test method: HPLC / USP method
Synonyms: Levomefolic acid, L-5-MTHF, 5-Methyltetrahydrofolate, L-Methylfolate, 5-MTHF-Ca
MOQ: 1 KG | Package: 1kg/foil bag (light-protected), 25kgs/drum
Certificate: HACCP, ISO 22000, GMP, HALAL (available upon request)
Molecular Formula: C₂₀H₂₃CaN₇O₆ (calcium salt) | CAS: 151533-22-1

Product Characteristics

🧂

Appearance

White to light yellow or beige crystalline powder.

⚗️

Purity

≥98% – ≥99% (HPLC) - high-purity bioactive folate.

🧬

Form

Biologically active form - no conversion needed.

💧

Solubility

Sparingly soluble in water; soluble in alkaline solutions.

🔬

Salt Form

Calcium salt - improved stability and shelf-life.

🏭

GMP Manufacturing

Produced in certified facilities with full traceability.

COA (Certificate of Analysis)

Note: Specifications vary by grade. This COA represents a typical high-purity (≥98%) calcium salt grade.

Test Item	Specification	Test Result	Conclusion
Appearance	White to light yellow/beige powder	Conforms	Pass
Assay (HPLC)	≥98.0%	98.6%	Pass
Identification (HPLC)	Conforms to reference standard	Conforms	Pass
Loss on Drying	≤5.0%	2.8%	Pass
Heavy Metals (as Pb)	≤10 ppm	<2 ppm	Pass
Lead (Pb)	≤1 ppm	<0.3 ppm	Pass
Total Plate Count	≤1,000 CFU/g	<100 CFU/g	Pass
E. Coli / Salmonella	Negative	Negative	Pass

Benefits of L-5-Methyltetrahydrofolic Acid Powder

01Active Form of Folate - No Conversion Needed

L-5-MTHF is the biologically active form of folate, directly participating as a methyl donor in the conversion of homocysteine to methionine. Supports normal homocysteine levels and overall cardiovascular health.

02Bypasses MTHFR Enzyme Limitations

Individuals with MTHFR gene polymorphisms cannot efficiently convert folic acid to L-5-MTHF. Direct supplementation eliminates this rate-limiting step, ensuring adequate folate status regardless of genetic makeup.

03Essential for Fetal Development

Adequate folate intake is critical during early pregnancy to help prevent neural tube defects. As a more bioavailable alternative to folic acid, L-5-MTHF is a key component in advanced prenatal nutrition formulations.

04Cardiovascular Support

L-5-MTHF supports healthy cardiovascular function by maintaining normal homocysteine levels, a key marker for cardiovascular health.

05Superior Stability as Calcium Salt

Stabilized as a calcium salt, offering improved shelf-life and storage stability compared to other forms of active folate. Ideal for advanced dietary supplements and functional foods.

06Clinically Recognized Safety Profile

JECFA has evaluated calcium L-5-methyltetrahydrofolate and established "no safety concern" for its proposed use in dietary supplements and foods for special dietary uses.

Application Fields

Dietary Supplements (Hero Application): Capsules & tablets (400–1,000 mcg), gummies & chewables, powder blends & stick packs, multivitamin & mineral blends (with B12 and B6).
Functional Foods & Beverages: Fortified beverages, nutrition bars, baked goods (microencapsulated grades).
Clinical Nutrition: Medical foods for patients with MTHFR deficiencies or malabsorption conditions.
OEM Finished Products: Prenatal vitamins, methylation support formulas, cardiovascular health supplements - full custom manufacturing available.

Production Process

Production process of L-5-MTHF

Process: Multi-step chemical synthesis → ion-exchange chromatography & crystallization → calcium salt formation → gentle drying → milling & sieving → QC testing → inert gas packaging.

Product Quality Advantage

≥98% – ≥99% Purity – High-purity bioactive folate.

Active Form – No conversion needed; bypasses MTHFR limitations.

Calcium Salt – Enhanced stability and shelf-life.

Low Heavy Metals – Pb <0.3 ppm.

Clinically Recognized – JECFA "no safety concern" status.

cGMP Certified – Full traceability and documentation.

Annual Capacity: 1,500 Tons | 15+ years of bioactive compound expertise

Professional ODM/OEM Services

We provide full OEM/ODM manufacturing for finished products using L-5-Methyltetrahydrofolic Acid as the active ingredient - from concept to commercial delivery, all under one roof.

① Finished Dosage Forms
Capsules & Tablets: 400 mcg, 800 mcg, 1,000 mcg; custom sizes and colors.
Chews & Gummies: Custom flavors, sugar‑free options.
Powder Blends: Stick packs, tubs; with Vitamin B12, B6, methyl donors.
Bars: Protein bars, snack bars.
Liquids: Solutions, ready-to-drink (special solubility grades).

② Combination Options
L-5-MTHF + Methyl B12 + B6 (methylation support), L-5-MTHF + Iron (prenatal), L-5-MTHF + Omega-3 (cardiovascular).

③ Additional Services
Flavor development, third‑party certification (NSF, Informed Sport, Kosher, HALAL), stability testing (light protection), regulatory documentation.

📧 Email: wangjing@landnutra.com

📱 WhatsApp: +86 18092657549

All backed by LANDNUTRA's quality assurance - full GMP, Halal, Kosher, COA certification and complete traceability from sourcing to finished product.

Export Certificates

Certificates HACCP ISO GMP Halal

Why choose us

XI'AN LANDNUTRA CO., LTD. – Your Trusted Manufacturer of Functional Ingredients. Rooted in Quality, Driven by Expertise, Committed to Health and Excellence.

Strong Production Capability: Annual capacity 1,500 tons. 15+ years experience, own facility.
Leading Service: ONE-STOP OEM/ODM from pre-sales to after-sales.
Quality Assurance: CQC-certified enterprise, purity embedded in every process.
Broad Market: Botanical Extracts, Cosmetic Ingredients, Functional Ingredients.

15+ years of experience in functional ingredients and bioactive compounds. Vertically integrated from raw material sourcing to finished goods manufacturing. Batch‑specific COA including HPLC assay, heavy metals, loss on drying, and microbial limits. Technical support for formulation and stability.

FAQ

Q1: What is the difference between L-5-MTHF and folic acid?

A: L-5-MTHF is the biologically active, naturally occurring form of folate. Folic acid is the synthetic form used in many supplements and fortified foods. The body must convert folic acid to L-5-MTHF through a multi-step enzymatic process. Individuals with MTHFR polymorphisms have a reduced ability to perform this conversion, making L-5-MTHF a more effective and direct option for supplementation.

Q2: What is the recommended daily dose?

A: Typical supplemental doses range from 400 mcg to 1,000 mcg per day, depending on the target population (e.g., general health vs. prenatal support). Always consult a healthcare provider for personalized recommendations.

Q3: Is L-5-MTHF safe?

A: L-5-MTHF has an excellent safety profile. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) has evaluated calcium L-5-methyltetrahydrofolate and established "no safety concern" for its proposed use in dietary supplements and foods for special dietary uses.

Q4: How should L-5-MTHF be stored?

A: Store in the original sealed container, protected from light, under cool, dry conditions. For long-term stability, store at -20°C. While it can be stored at 2-8°C for short-term use, -20°C is recommended for extended periods to prevent degradation. Once opened, use promptly and keep container tightly sealed.

Q5: Is L-5-MTHF vegan?

A: Yes. Our L-5-MTHF is produced via chemical synthesis. It does not contain any animal-derived components.

Q6: What is the shelf life?

A: 24 months in original sealed container under recommended storage conditions. Stability is enhanced by light-protected packaging and proper storage.

Q7: Can L-5-MTHF be used in clear liquid supplements?

A: L-5-MTHF is sparingly soluble in water. It is best suited for capsules, tablets, powder blends, and opaque beverages. For functional beverage applications, consider microencapsulated or special solubility grades. Our formulation experts can advise on the best grade for your specific application.

Q8: Why is L-5-MTHF often sold as a calcium salt?

A: The calcium salt form offers improved stability and shelf-life compared to the free acid form. It is the most common and commercially viable form for dietary supplement applications.

Q9: Can L-5-MTHF be combined with Vitamin B12?

A: Yes - this is a common and synergistic combination. Both are key players in the methylation cycle. L-5-MTHF donates a methyl group, and vitamin B12 (especially methylcobalamin) acts as a co-factor. Together they support cardiovascular and neurological health.

Q10: Is L-5-MTHF suitable for gummies?

A: Yes - with proper formulation. Its neutral taste and stability make it suitable for gummies and chewable supplements. Our formulation team can advise on stability and formulation.

Q11: Can L-5-MTHF be used in baked goods?

A: Yes - microencapsulated grades are engineered to withstand the stresses of high-temperature baking processes, improving stability during production. Our team can recommend the appropriate grade for your application.

Q12: Who should consider L-5-MTHF over folic acid?

A: Individuals with MTHFR polymorphisms, those looking for the most bioavailable folate form, pregnant women seeking optimal prenatal nutrition, and anyone who wants to ensure they are getting the active form of folate without relying on enzymatic conversion.

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