Description

Alpha Glycerol Phosphocholine Powder

Alpha Glycerol Phosphocholine (Alpha-GPC) is a highly bioavailable source of choline, a naturally occurring compound found in the brain and in food sources. It is a water-soluble phospholipid metabolite that can efficiently cross the blood-brain barrier, serving as a direct biosynthetic precursor to the neurotransmitter acetylcholine and a source of choline for cell membrane phospholipids.

🧠 The "Membrane Builder and Neurotransmitter Precursor" Mechanism: Alpha-GPC delivers choline to the brain more efficiently than many other choline sources, supporting the synthesis of acetylcholine, a neurotransmitter critical for memory, learning, and muscle function. Additionally, alpha-GPC provides glycerophosphate, which helps support neuronal membrane integrity and fluidity. Unlike other choline salts, it is tasteless and 100% soluble in water, making it highly versatile for formulation.

Cognitive and Physical Performance: Research indicates that alpha-GPC may enhance cognitive performance, including processing speed and executive function, particularly in healthy populations. In athletes, alpha-GPC supplementation may help prevent exercise-induced reductions in choline levels and increase endurance performance and growth hormone secretion.

🌡️ Storage Note: Alpha-GPC is highly hygroscopic. Store in original sealed container under cool, dry conditions (≤25°C, ≤60% RH). Protect from moisture. Once opened, use within 12 months and keep tightly sealed.

💧 Handling Note: Due to its hygroscopic nature, Alpha-GPC powder should be handled in low-humidity environments (<60% RH). Seal tightly after each use to prevent clumping.

Specification: ≥98.0% – 99.0% (HPLC, on dried basis)
Sample: Sample Available
Test method: HPLC / LC-MS / Titration
Synonyms: L-α-Glycerylphosphorylcholine, L-α-GPC, Choline Alfoscerate, GPC, Glycerophosphocholine, sn-Glycero-3-phosphocholine
MOQ: 1 KG | Package: 1kg/foil bag (light-protected), 25kgs/drum
Certificate: HACCP, ISO 22000, GMP, HALAL (available upon request), Kosher (available upon request)
Molecular Formula: C₈H₂₀NO₆P | CAS: 28319-77-9

Product Characteristics

🧂

Appearance

White to off-white fine powder; odorless.

⚗️

Purity

≥98% – ≥99% (HPLC) - high-purity nutritional grade.

🧠

Brain Bioavailability

Rapidly crosses blood-brain barrier; direct acetylcholine precursor.

💧

Solubility

100% water-soluble; tasteless - ideal for beverages.

🔬

Source

Derived from soy lecithin (sunflower available upon request).

🏭

GMP Manufacturing

Produced in certified facilities with full traceability.

COA (Certificate of Analysis)

Note: Specifications vary by grade. This COA represents a typical high-purity (≥99%) grade.

Test Item	Specification (≥99% Grade)	Test Result	Conclusion
Appearance	White to off-white fine powder	Conforms	Pass
Assay (HPLC)	≥99.0%	99.4%	Pass
Identification (LC-MS)	Conforms to reference standard	Conforms	Pass
Specific Optical Rotation	-2.4° to -3.0°	-2.7°	Pass
pH (1% solution)	7.5 – 9.0	8.2	Pass
Loss on Drying	≤2.0%	0.8%	Pass
Heavy Metals (as Pb)	≤10 ppm	<2 ppm	Pass
Total Plate Count	≤1,000 CFU/g	<100 CFU/g	Pass
E. Coli / Salmonella	Negative	Negative	Pass

Benefits of Alpha Glycerol Phosphocholine Powder

01Cognitive Enhancement

Alpha-GPC rapidly delivers choline to the brain across the blood-brain barrier, serving as a biosynthetic precursor to acetylcholine and other phospholipids. Supports memory, learning, and processing speed. Extensive clinical evidence demonstrates GPC effectively alleviates cognitive impairment associated with Alzheimer's disease, vascular dementia, cerebral ischemia, and stress.

02Athletic Performance

In athletes, alpha-GPC supplementation prevents exercise-induced reductions in choline levels, increasing endurance performance and growth hormone secretion. Supports focus, strength, and power output during training.

03Neuroprotection & Healthy Aging

Alpha-GPC has been studied for its potential neuroprotective properties and may improve cognition in patients with dementia. It supports neuronal membrane integrity and promotes hippocampal neurogenesis.

04Growth Hormone Support

Alpha-GPC administration has been associated with increased growth hormone secretion, supporting muscle recovery, metabolism, and overall vitality.

05Membrane Integrity

Unlike some choline sources, alpha-GPC provides both choline and glycerophosphate components, which work synergistically to support neuronal membrane integrity and optimize neurotransmitter synthesis.

06GRAS & Regulatory Approved

FDA-determined GRAS for use in beverages and foods. EFSA concluded L-alpha-GPC does not raise safety concerns in food supplements. Approved as a New Food Ingredient in China (March 2024).

Application Fields

Dietary Supplements (Hero Application): Capsules & tablets (300–600 mg), powder blends & stick packs, gummies & chewables, multivitamin & nootropic blends.
Sports Nutrition: Pre-workout formulas, recovery blends, endurance support.
Functional Foods & Beverages: Fortified beverages, ready-to-drink liquids, nutrition bars.
Clinical Nutrition: Cognitive health formulations for healthy aging.
OEM Finished Products: Cognitive support capsules, nootropic powder sticks, pre-workout gummies, custom performance blends - full custom manufacturing available.

Production Process

Production process of Alpha-GPC

Process: Natural lecithin sourcing → enzymatic/chemical hydrolysis → resin & silica gel column chromatography purification → gentle drying → milling & sieving → QC testing → moisture-proof packaging.

Product Quality Advantage

≥98% – ≥99% Purity – High-purity nutritional grade.

100% Water-Soluble – Tasteless, ideal for beverages.

Rapid Brain Delivery – Crosses blood-brain barrier efficiently.

Low Heavy Metals – Pb <0.3 ppm.

GRAS & Novel Food Approved – FDA, EU, China approved.

cGMP Certified – Full traceability and documentation.

Annual Capacity: 1,500 Tons | 15+ years of nootropic compound expertise

Professional ODM/OEM Services

We provide full OEM/ODM manufacturing for finished products using Alpha Glycerol Phosphocholine as the active ingredient - from concept to commercial delivery, all under one roof.

① Finished Dosage Forms
Capsules & Tablets: 300 mg, 600 mg; custom sizes and colors.
Chews & Gummies: Custom flavors, sugar‑free options.
Powder Blends: Stick packs, tubs; with Citicoline, L-Tyrosine, B-vitamins.
Liquids: Ready-to-drink beverages, tinctures.
Bars: Protein bars, snack bars.

② Combination Options
Alpha-GPC + Citicoline (synergistic nootropic stack), Alpha-GPC + L-Tyrosine (focus + energy), Alpha-GPC + Bacopa (memory support), Alpha-GPC + Phosphatidylserine (stress management).

③ Additional Services
Flavor development, third‑party certification (NSF, Informed Sport, Kosher, HALAL), stability testing (moisture control), regulatory documentation.

📧 Email: wangjing@landnutra.com

📱 WhatsApp: +86 18092657549

All backed by LANDNUTRA's quality assurance - full GMP, Halal, Kosher, COA certification and complete traceability from sourcing to finished product.

Export Certificates

Certificates HACCP ISO GMP Halal Kosher

Why choose us

XI'AN LANDNUTRA CO., LTD. – Your Trusted Manufacturer of Functional Ingredients. Rooted in Quality, Driven by Expertise, Committed to Health and Excellence.

Strong Production Capability: Annual capacity 1,500 tons. 15+ years experience, own facility.
Leading Service: ONE-STOP OEM/ODM from pre-sales to after-sales.
Quality Assurance: CQC-certified enterprise, purity embedded in every process.
Broad Market: Botanical Extracts, Cosmetic Ingredients, Functional Ingredients.

15+ years of experience in functional ingredients and nootropic compounds. Vertically integrated from raw material sourcing to finished goods manufacturing. Batch‑specific COA including HPLC assay, optical rotation, heavy metals, loss on drying, and microbial limits. Technical support for formulation and stability.

FAQ

Q1: What is the difference between Alpha-GPC and other choline sources?

A: Alpha-GPC is one of the most bioavailable choline sources, efficiently crossing the blood-brain barrier to deliver choline directly to the brain. Unlike some choline salts, it does not have a fishy odor and is tasteless. It also provides glycerophosphate, which supports neuronal membrane integrity.

Q2: What is the recommended dosage?

A: Typical doses range from 300–600 mg per day for cognitive support. In the US, the FDA has determined that intake of no more than 203.7 mg/day (corresponding to 82.5 mg/day of choline) is GRAS for use in conventional foods. In the EU, the proposed maximum use level is 203.7 mg/day in food supplements. For specific applications, clinical studies have used 800 mg/day for up to 11 months.

Q3: Is Alpha-GPC better than other choline sources?

A: Alpha-GPC is one of the most bioavailable choline sources, efficiently crossing the blood-brain barrier to deliver choline directly to the brain. Unlike some choline salts, it does not have a fishy odor. It also provides glycerophosphate, which supports neuronal membrane integrity.

Q4: Does Alpha-GPC cause side effects?

A: Alpha-GPC is generally well-tolerated at recommended doses. Some individuals may experience mild gastrointestinal upset, headache, or insomnia if taken close to bedtime. It should not be combined with cholinergic drugs without medical supervision. Extensive human studies indicate GPC causes no severe adverse effects.

Q5: Is Alpha-GPC vegan?

A: Our Alpha-GPC can be sourced from non-animal origins (e.g., soy lecithin or sunflower lecithin). Please confirm specific batch sourcing for vegan suitability.

Q6: Why does Alpha-GPC powder clump easily?

A: High-purity Alpha-GPC is highly hygroscopic, meaning it readily absorbs moisture from the air. To prevent clumping, seal the container tightly after each use and store in a cool, dry place.

Q7: What is the shelf life?

A: 24 months in original sealed container under cool, dry conditions (≤25°C, ≤60% RH). Protect from moisture. Once opened, use within 12 months and keep container tightly sealed.

Q8: Can Alpha-GPC be used in clear liquid supplements?

A: Yes. Alpha-GPC is freely soluble in water and tasteless, making it highly suitable for clear liquid formulations and ready-to-drink beverages.

Q9: Can Alpha-GPC be combined with other nootropics?

A: Yes - Alpha-GPC is often combined with Citicoline for synergistic choline support, with L-Tyrosine for focus and energy, with Bacopa monnieri for memory support, or with Phosphatidylserine for stress management. Our formulation team can advise on optimal combinations and ratios.

Q10: What is the difference between Alpha-GPC and choline bitartrate?

A: Alpha-GPC is significantly more bioavailable than choline bitartrate. It crosses the blood-brain barrier more efficiently and delivers choline directly to the brain. Choline bitartrate is a cheaper, less effective form of choline that requires conversion and has lower absorption rates.

Q11: Can Alpha-GPC be used in pre-workout formulas?

A: Yes - Alpha-GPC is a popular ingredient in pre-workout supplements due to its ability to increase growth hormone secretion, enhance muscle strength and power output, and improve focus during training. Typical pre-workout doses range from 300–630 mg.

Q12: Is Alpha-GPC suitable for gummies?

A: Yes - with proper formulation. Its neutral taste and water solubility make it suitable for gummies and chewable supplements. However, its hygroscopic nature must be managed during manufacturing. Our formulation team can advise on stability and formulation.

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