Description

N-Acetylneuraminic Acid Powder

N-Acetylneuraminic acid (Neu5Ac), commonly known as sialic acid, is a nine-carbon sugar molecule that plays a fundamental role in human biology. It is a major component of glycoconjugates-such as glycolipids, glycoproteins, and proteoglycans-where it occupies the terminal position on these complex molecules, conferring selective binding characteristics.

🧬 The "Terminal Sugar" for Cellular Recognition and Health: Neu5Ac is often found as the terminal sugar of cell surface glycoproteins, where it plays critical roles in cell recognition, cell adhesion, and intercellular interaction. Cell surface glycoproteins are also important in tumor growth and metastases.

Biosynthesis and Physiological Context: Neu5Ac is the most abundant sialic acid in humans and serves as the biosynthetic precursor of most other sialic acids. It is involved in a wide range of biological processes, including immune modulation (acting as "self" markers), brain development and cognition (concentrated in brain gangliosides), and muscle health (deficiencies are associated with inherited muscle diseases).

❄️ Storage Note: N-Acetylneuraminic acid should be stored at −20°C in the original sealed container, protected from light. It is stable for 24 months under these conditions.

Specification: ≥98.0% (HPLC, on anhydrous basis)
Sample: Sample Available
Test method: HPLC / UV-Vis
Synonyms: N-Acetylneuraminic acid, NANA, Neu5Ac, Sialic acid, 5-Acetamido-3,5-dideoxy-D-glycero-D-galactononulosonic acid, Lactaminic acid
MOQ: 1 KG | Package: 1kg/foil bag, 25kgs/drum
Certificate: HACCP, ISO 22000, GMP, Kosher (available upon request)
Molecular Formula: C₁₁H₁₉NO₉ | CAS: 131-48-6

Product Characteristics

🧂

Appearance

White to off-white crystalline powder; odorless.

⚗️

Purity

≥98% (HPLC) - high-purity sialic acid.

💧

Solubility

~50 mg/mL in water - clear, colorless solution.

🧬

Role

Terminal sugar in glycoconjugates; cell recognition and adhesion.

📏

Particle Size

>95% pass 80 mesh.

🏭

GMP Manufacturing

Produced in certified facilities with full traceability.

COA (Certificate of Analysis)

Benefits of N-Acetylneuraminic Acid Powder

01Essential Component of Glycoconjugates

Neu5Ac is a key component of glycoconjugates such as glycolipids, glycoproteins, and proteoglycans, where it confers selective binding characteristics essential for cellular function.

02Cell Recognition and Adhesion

As the terminal sugar of cell surface glycoproteins, Neu5Ac plays important roles in cell recognition and interaction as well as in cell adhesion.

03Brain and Cognitive Health

Sialic acid is concentrated in brain tissue and is critical for neural development, synaptic plasticity, and cognitive function. Supports brain health and mental clarity.

04Muscle Health and Neuromuscular Disorders

Deficiencies in sialic acid biosynthesis are linked to neuromuscular diseases such as GNE myopathy. Supplementation is being investigated as a therapeutic strategy.

05Immune Modulation

Sialic acids on cell surfaces act as "self" markers, modulating immune recognition and preventing inappropriate immune responses.

06Novel Food Compliant & High Purity

Meets EU Novel Food Union List specifications with strict controls on residual proteins, solvents, heavy metals, and endotoxins.

Application Fields

Dietary Supplements (Hero Application): Capsules & tablets (for cognitive and neuromuscular health), powdered drink mixes, gummies & chewables, specialized formulations for sialic acid metabolism conditions.
Pharmaceuticals & Research: API for drug formulations, cell culture media, research material for glycobiology and metabolomics.
Food & Nutrition: Functional foods & beverages, infant formula (as a component of human milk oligosaccharides).
OEM Finished Products: Cognitive support capsules, neuromuscular support formula, brain health gummies, protein bars, custom sialic acid precursor blends - full custom manufacturing available.

Production Process

Production process of N-Acetylneuraminic Acid

Process: Microbial fermentation → ion‑exchange chromatography → crystallization → gentle drying → milling → sieving → light‑protected packaging.

Product Quality Advantage

≥98% Purity – HPLC verified, high‑quality sialic acid.

Novel Food Compliant – Meets EU Union List specifications.

Low Heavy Metals – Pb <0.05 mg/kg, Fe <5 mg/kg.

Low Endotoxins – <5 EU/mg, suitable for pharmaceutical use.

Excipient‑Free – 100% active ingredient.

cGMP Certified – Full traceability and documentation.

Annual Capacity: 1,500 Tons | 15+ years of carbohydrate chemistry expertise

Professional ODM/OEM Services

We provide full OEM/ODM manufacturing for finished products using N-Acetylneuraminic Acid as the active ingredient - from concept to commercial delivery, all under one roof.

① Finished Dosage Forms
Capsules: 100 mg, 200 mg, 500 mg; vegetarian/gelatin; custom bottle/blister.
Tablets: Direct compression; round/oval; debossing.
Chews & Gummies: Custom flavors, sugar‑free options.
Powder Blends: Stick packs, tubs; with ManNAc, other precursors.
Liquids: Solutions, suspensions, ready‑to‑drink.
Bars: Protein bars, snack bars.

② Combination Options
Neu5Ac + ManNAc (sialic acid precursor synergy), Neu5Ac + Cognitive Support Blends.

③ Additional Services
Flavor development, third‑party certification (NSF, Kosher, HALAL), stability testing, regulatory documentation (EU Novel Food compliance support).

📧 Email: wangjing@landnutra.com

📱 WhatsApp: +86 18092657549

All backed by LANDNUTRA's quality assurance - full GMP, Halal, Kosher, COA certification and complete traceability from sourcing to finished product.

Export Certificates

Certificates HACCP ISO GMP Kosher

Why choose us

XI'AN LANDNUTRA CO., LTD. – Your Trusted Manufacturer of Functional Ingredients. Rooted in Quality, Driven by Expertise, Committed to Health and Excellence.

Strong Production Capability: Annual capacity 1,500 tons. 15+ years experience, own facility.
Leading Service: ONE-STOP OEM/ODM from pre-sales to after-sales.
Quality Assurance: CQC-certified enterprise, purity embedded in every process.
Broad Market: Botanical Extracts, Cosmetic Ingredients, Functional Ingredients.

15+ years of expertise in functional ingredients and carbohydrate chemistry. Vertically integrated from raw material sourcing to finished goods manufacturing. Batch‑specific COA including assay, pH, water content, heavy metals, residual proteins, residual solvents, endotoxins, and microbiological limits. Technical support for formulation and stability.

FAQ

Q1: What is N-Acetylneuraminic acid?

A: N-Acetylneuraminic acid (Neu5Ac), commonly known as sialic acid, is a nine-carbon sugar molecule that is a major component of glycoconjugates such as glycolipids, glycoproteins, and proteoglycans. It is the most abundant sialic acid in humans and plays critical roles in cell recognition, cell adhesion, and immune modulation.

Q2: What is the role of N-Acetylneuraminic acid in the body?

A: Neu5Ac is found as the terminal sugar of cell surface glycoproteins, where it plays important roles in cell recognition and interaction as well as in cell adhesion. It is also concentrated in brain tissue and is critical for neural development and cognitive function.

Q3: What is the relationship between N-Acetylneuraminic acid and GNE myopathy?

A: GNE myopathy is a rare genetic muscle disease caused by mutations in the GNE gene, which encodes the rate-limiting enzyme for intracellular sialic acid biosynthesis. These mutations lead to decreased sialic acid production. Supplementation with sialic acid precursors is being investigated as a therapeutic strategy.

Q4: Is N-Acetylneuraminic acid absorbed when taken orally?

A: Yes. Orally administered free NeuNAc is rapidly absorbed but also rapidly excreted in the urine. Studies have shown that plasma free NeuNAc increases significantly within hours of oral administration.

Q5: What is the recommended daily dosage?

A: Clinical studies have used doses of 150 mg/kg/day (divided into three doses) for pediatric patients. Always consult a healthcare provider for personalized recommendations, especially for therapeutic applications.

Q6: Is N-Acetylneuraminic acid vegan?

A: Yes. Our N-Acetylneuraminic acid is produced via microbial fermentation or chemical synthesis. It does not contain any animal-derived components.

Q7: What is the shelf life?

A: 24 months in original sealed container when stored at −20°C, protected from light. Once opened, use within 12 months and keep container tightly sealed.

Q8: Is N-Acetylneuraminic acid stable in solution?

A: Neu5Ac is soluble in water up to 50 mg/mL, forming a clear and colorless solution. Solutions should be prepared fresh and protected from heat and prolonged exposure to light.

Q9: What are the specifications for Novel Food grade N-Acetylneuraminic acid?

A: The EU Novel Food Union List specifies strict criteria: pH 1.7–2.5, >97.0% assay, ≤12.5% water, <0.2% sulphated ash, strict heavy metal limits (Pb <0.1 mg/kg, Fe <20.0 mg/kg), <0.01% residual proteins, residual solvent limits, and strict microbiological criteria including endotoxins <10 EU/mg.

Q10: Can N-Acetylneuraminic acid be used in infant formula?

A: Yes. As a component of human milk oligosaccharides (HMOs), sialic acid is important for infant brain development and is a permitted ingredient in certain infant nutrition applications.

Q11: Is N-Acetylneuraminic acid stable at room temperature?

A: For long-term stability, storage at −20°C is recommended. The powder may be stable for short periods at room temperature, but prolonged exposure should be avoided to prevent degradation.

Q12: Can N-Acetylneuraminic acid be combined with other cognitive support ingredients?

A: Yes. It can be formulated with other nootropics, B‑vitamins, and omega‑3 fatty acids for comprehensive cognitive support. Our formulation team can advise on optimal combinations.

Test Item	Specification (Novel Food / USP Grade)	Test Result	Conclusion
Appearance	White to off-white crystalline powder	Conforms	Pass
Assay (HPLC)	≥98.0%	99.4%	Pass
pH (5% solution)	1.7 – 2.5	2.0	Pass
Water Content (KF)	≤12.5%	8.5%	Pass
Residue on Ignition	<0.2%	0.07%	Pass
Lead (Pb)	<0.1 mg/kg	<0.05 mg/kg	Pass
Endotoxins	<10 EU/mg	<5 EU/mg	Pass
Total Plate Count	<500 CFU/g	<100 CFU/g	Pass
E. Coli / Salmonella	Negative	Negative	Pass

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