L- Ergothioneine Powder

L- Ergothioneine Powder

1.Specification: >= 99.0% (HPLC, on dried basis)
2. Sample: Sample Available
3. Test method: HPLC / Titration / ICP-MS / ¹H-NMR / Elemental analysis
4. Synonyms: L-(+)-Ergothioneine, EGT, ET, 2-Mercaptohistidine trimethylbetaine, Thiasine, Thioneine, Sympectothion, (S)-α-Carboxy-N,N,N-trimethyl-2-mercapto-1H-imidazole-4-ethanaminium inner salt
5. Appearance: White to off-white crystalline powder, odorless
6. Particle size: >95% pass 80 mesh
7. MOQ: 1 KG
8. Package: 1kg/foil bag (double-sealed, light-protected), 25kgs/fiber drum (lined with polyethylene)
9. Certificate: HACCP, ISO 22000, HALAL, GMP, Kosher (available upon request); conforms to USP specifications
10. Molecular Formula: C9H15N3O2S
11. CAS number: 497-30-3
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Description

 

 

L- ergothioneine powder

Our brand Landnutra supplies a high-purity bulk L-ergothioneine powder - a rare, naturally occurring amino acid derivative and potent antioxidant engineered to protect cells from oxidative stress, standardized to ≥99.0% purity by HPLC, specifically designed to support cellular health, promote healthy aging, protect mitochondria and maintain DNA integrity without pro-oxidant effects. This white to off-white crystalline powder dissolves readily in water, offers a neutral taste and fits clean-label functional foods, dietary supplements, skincare formulations and sports nutrition products - the preferred choice for brands sourcing bulk L-ergothioneine powder with consistent quality.
Specification: ≥99.0% (HPLC)
Sample: Sample Available
Test method: HPLC / Titration / ICP-MS / Optical Rotation / ¹H-NMR
Synonyms: L-(+)-Ergothioneine, EGT, ET, 2-Mercaptohistidine trimethylbetaine, Thiasine, Thioneine, Sympectothion
MOQ: 1 KG | Package: 1kg/aluminum foil bag (double-sealed, light-protected), 25kgs/fiber drum
Certificate: HACCP, ISO 22000, HALAL, GMP, Kosher (available upon request)
Molecular Formula: C₉H₁₅N₃O₂S | CAS: 497-30-3

L- ergothioneine powder
Product Characteristics
 
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Appearance
White to off-white ultra-fine powder, free-flowing, practically odorless.

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Purity
≥99.0% (HPLC area normalization), typical assay 99.4% - ensuring batch-to-batch reliability.

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Solubility
Rapidly soluble in water at room temperature (≥50 g/L), forming a clear solution; sparingly soluble in absolute ethanol.

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pH (1% Solution)
5.0 – 7.0, suitable for neutral and mildly acidic formulations.

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Particle Size
≥95% through 80 mesh; micronized grades down to D50 ≤10 μm available for superior blend uniformity in tablets and capsules.

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Production Process
Produced via microbial fermentation extraction from L-histidine as starting material, under cGMP with full traceability - vegan, non-GMO.

Benefits of L- ergothioneine powder

1.Powerful Antioxidant Activity: L-Ergothioneine is a natural intracellular antioxidant with free radical scavenging capacity superior to CoQ10 and Vitamin E, protecting cells from oxidative damage.

2.Targeted Mitochondrial Protection: L-Ergothioneine enters mitochondria via OCTN1 transporter, precisely scavenging mitochondrial free radicals and delaying cellular aging.

3.Clinically Supported Benefits: Extensive preclinical and human clinical studies confirm its efficacy in cognitive health, skin protection, liver health and eye health, reducing market education costs.

4.Stable & Non-Pro-Oxidant: L-Ergothioneine exhibits no pro-oxidant side effects under physiological conditions, with high safety profile suitable for long-term use.

5.Broad Formulation Compatibility: Synergistic with Vitamin C, Vitamin E, CoQ10, Astaxanthin, plant extracts and other antioxidant ingredients. Suitable for capsules, tablets, solid drinks, gummies, oral liquids and skincare products.

Application Fields

1.Dietary Supplements: Used in anti-aging, brain health and immune support capsules, tablets and powders to protect cells from oxidative damage.
2. Sports Nutrition: Used in endurance enhancement and post-workout recovery products to reduce exercise-induced oxidative stress and muscle fatigue.
3. Functional Beverages: Used in RTD drinks and powdered drink mixes to provide long-lasting antioxidant protection and vitality enhancement.
4. Beauty-from-Within: Used in collagen drinks, skin brightening tablets and other oral beauty products to protect skin from photoaging and maintain skin elasticity and radiance.
5. Wellness Gummies: Used in chewable nutritional supplements with neutral taste for easy flavoring, suitable for young and middle-aged consumers.

Production Process

L- ergothioneine powder production process

Product Quality Advantage

Superior Purity: HPLC purity ≥99.0% with typical assay of 99.4%, ultra-low impurity levels, conforming to global quality standards for dietary supplements and pharmaceutical excipients.
Natural Fermentation Source: Produced via microbial fermentation extraction, no chemical synthesis, retaining 100% natural L-isomer configuration with full biological activity.
High Optical Purity: Optical rotation strictly controlled within standard limits, ensuring pure natural L-form with no D-form impurities interfering with physiological activity.
Controlled Moisture & Residue: Loss on drying ≤0.5%, residue on ignition ≤0.2%, ensuring product stability and extended shelf life.
Batch-to-Batch Consistency: Strict process control and finished product testing ensure consistent key indicators including assay, moisture, ash and optical rotation across batches, guaranteeing reproducibility of end-product formulations.
Strict Quality Control System: Produced in cGMP workshops with full-process monitoring. Each batch comes with complete COA. Third-party testing by SGS, Eurofins or other accredited labs is supported.
L- ergothioneine powder factory
L- ergothioneine powderQuality Control LabAnnual Capacity: 1,500 Tons | 15+ years of cosmetic active ingredient expertise

Professional ODM/OEM Services

Our brand Landnutra provides full-service finished product manufacturing with L-Ergothioneine Powder as the active:

Finished Dosage Forms – 250mg/500mg vegetarian or gelatin capsules; direct-compression or wet-granulation tablets (debossing available); instant powder stick packs (blended with Vitamin C, Vitamin E, Astaxanthin, CoQ10); chewable gummies and effervescent tablets; ready-to-drink antioxidant & anti-aging functional beverages.

Additional Support – Flavor masking, sweetener system optimization, third-party certifications (Kosher, HALAL, NSF), accelerated stability studies, label claim review and regulatory dossier compilation.

Beyond L-Ergothioneine, our brand Landnutra also supplies Glutathione powder (potent intracellular antioxidant) and Astaxanthin powder (lipid-soluble antioxidant powerhouse) - allowing cross-category sourcing under the same quality system.

As dedicated L-ergothioneine powder manufacturers, we provide scalable supply from 1-kg evaluation samples to multi-ton bulk orders, supporting wholesale L-ergothioneine powder with flexible MOQs; for the latest L-ergothioneine powder price list or a tailored quotation, reach out at Email: wangjing@landnutra.com or WhatsApp: +86 18092657549 - we respond within one business day with full technical documentation.

FAQ

Q1: What is the difference between L-Ergothioneine and other antioxidants (e.g., Vitamin C, CoQ10, Astaxanthin)?
A1: L-Ergothioneine is the only antioxidant with its own specific transporter (OCTN1) to enter cells and mitochondria, achieving millimolar intracellular concentrations. Its free radical scavenging capacity surpasses Vitamin C and CoQ10, with no pro-oxidant side effects.
Q2: What is the regulatory status of L-Ergothioneine?
A2: L-Ergothioneine has received EU Novel Food approval, US GRAS certification, and has been approved as a New Food Ingredient in China, meeting major global market access requirements.
Q3: What is the shelf life of the product?
A3: 24 months when stored unopened under cool dry conditions.
Q4: Does L-Ergothioneine have a bitter taste or off-odor? Which dosage forms are suitable?
A4: L-Ergothioneine has a neutral taste with practically no odor, easy to flavor. It is ideal for capsules, tablets, gummies, oral liquids, solid drinks and skincare products.
Q5: Can free samples be provided?
A5: Yes, we offer free samples for formula verification and testing.
Q6:  What precautions should be taken when compounding L-Ergothioneine with other raw materials?
A6: L-Ergothioneine has broad formula compatibility with Vitamin C, Vitamin E, Astaxanthin, CoQ10, Glutathione, plant extracts and other ingredients. Small-scale sample testing is recommended to confirm system stability before production.

 

Test Item Specification (USP Grade) Test Result Conclusion
Appearance White to off-white crystalline powder Conforms Pass
Assay (HPLC) ≥99.0% 99.4% Pass
Loss on Drying ≤0.5% 0.22% Pass
Residue on Ignition ≤0.2% 0.06% Pass
Chlorides (Cl) ≤0.005% <0.005% Pass
Heavy Metals (as Pb) ≤10 ppm <2 ppm Pass
Lead (Pb) ≤1 ppm <0.5 ppm Pass
Arsenic (As) ≤1 ppm <0.5 ppm Pass
Cadmium (Cd) ≤1 ppm <0.1 ppm Pass
Mercury (Hg) ≤0.1 ppm <0.01 ppm Pass
Optical Rotation +120° ~ +130° +126.3° Pass
Total Aerobic Microbial Count ≤1,000 cfu/g <100 cfu/g Pass
E. Coli Negative Negative Pass
Salmonella Negative Negative Pass

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