Product Description
Our Pure PDRN Powder is a highly purified pharmaceutical-grade extract of Polydeoxyribonucleotide, derived from the milt (sperm) of wild, sustainably sourced salmon. Unlike low-grade ordinary PDRN produced from mixed farmed fish scraps, we adopt proprietary mild enzymatic hydrolysis and multi-stage purification to precisely extract active DNA fragments with molecular weight of 50–1500 kDa. Our powder achieves ≥95% purity with ultra-low endotoxin, free of residual protein, RNA and other contaminants, outperforming regular PDRN in purity, safety and batch stability under strict standardized production control. This bioactive polymer serves as an efficient tissue regenerating factor by activating the Adenosine A2A receptor pathway, accelerating cell proliferation, relieving inflammation, promoting angiogenesis and collagen synthesis. Conventional PDRN has irregular molecular weight, insufficient purity and fluctuating efficacy, only applicable to low-end daily skincare. Our pharmaceutical-grade wholesale Pure PDRN Powder delivers steady and powerful repairing performance, an ideal premium active raw material, supplied in bulk with batch-level documentation, for regenerative medicine, medical aesthetics and high-end cosmeceutical formulations.
As professional Pure PDRN Powder manufacturers and reliable Pure PDRN Powder suppliers, we provide bulk wholesale Pure PDRN Powder for cosmetic, medical and research enterprises across global markets.
PDRN vs PN is a technical comparison that formulators increasingly search, and the difference is molecular structure. Both are DNA-derived ingredients - PDRN is a fragmented, lower-molecular-weight polynucleotide, while PN retains longer chains and higher viscosity. That shapes formulation behavior: PDRN suits barrier and repair-focused serums and creams, while PN fits gel-type, more intensive formulas. It also shapes how the two are described: PDRN benefits for skin are framed around one theme - supporting the skin's own repair and renewal processes. Because it is DNA-derived and biocompatible, PDRN is positioned in anti-aging and barrier-care products for its reported role in supporting skin recovery, framed as "supports skin barrier and skin comfort" rather than medical claims. It works across serums, creams, masks and sticks, pairs with peptides and hyaluronic acid, and fits premium science-backed positioning. For sourcing, molecular weight and viscosity distinguish the two - suppliers should state which type a grade actually is.
Pure PDRN Powder Key Characteristics
Raw material: Wild salmon milt with low impurities, better than farmed-fish PDRN
Process: Proprietary gentle hydrolysis & multi-stage purification, fixed active fragment 50–1500 kDa
Efficacy: Activates Adenosine A2A pathway for anti-inflammation, cell regeneration, angiogenesis and collagen boost
Stability: Strict standardized production ensures identical performance per batch
Application: Suitable for aesthetic injections, post-procedure repair, regenerative medicine and high-end cosmeceuticals
COA (Certificate of Analysis)
|
Test Item |
Specification |
Test Result |
Test Method |
|
Appearance |
White to off-white powder |
Complies |
Visual |
|
Identification (HPLC) |
Complies with reference standard |
Complies |
HPLC |
|
Purity (PDRN Content) |
≥ 95.0% |
98.2% |
HPLC |
|
Molecular Weight Distribution |
50 - 1500 kDa |
Complies |
SEC-MALS |
|
Protein Content |
≤ 0.1% |
<0.05% |
BCA Method |
|
RNA Content |
≤ 0.1% |
<0.05% |
UV Spectrophotometry |
|
Endotoxin |
< 0.1 EU/mg |
< 0.05 EU/mg |
LAL Test |
|
Total Plate Count |
≤ 10 cfu/g |
< 10 cfu/g |
USP <61> |
|
Heavy Metals (Pb, As, Cd, Hg) |
≤ 10 ppm total |
Complies |
ICP-MS |
|
Residual Solvents |
Complies with ICH Q3C |
Complies |
GC-MS |
Processing Introduction
PDRN (Polydeoxyribonucleotide) Powder is mainly produced from salmon testes via a mature industrial process, with core steps simplified as follows:
1.Raw Material Preparation- Pick premium salmon testes, clear impurities, wash with cold saline and crush into slurry.
2.Cell Lysis -Mix pulp with lysis buffer & Proteinase K, incubate at 37℃ to lyse cells and eliminate protein/RNA.
3.DNA Extraction & Primary Purification -Separate DNA via phenol-chloroform extraction, precipitate with isopropanol, ethanol wash and dry.
4.Enzymatic Fragmentation -Digest DNA with DNase I at 35–40℃ to get 50–2000bp fragments, then heat to deactivate enzyme.
5.Deep Purification- Remove impurities and microbes through micro/nano/ultrafiltration; chromatography available for high-grade products.
6.Drying & Milling- Freeze/spray dry the liquid, grind and sieve to uniform 50–150μm powder.
7.QC & Packaging- Inspect purity (≥95%), molecular weight, microbes and heavy metals; nitrogen-seal and store at 2–8℃.
Benefits
Superior Safety & Regulatory Compliance
Recombinant PDRN carries no animal‑related contamination risk, with low endotoxin and low protein residue, meeting stringent medical and cosmetic standards (e.g., GMP, ISO 13485).
01
Superior Efficacy & Formulation Flexibility
Sequence‑optimized recombinant PDRN outperforms traditional extracts in promoting VEGF and collagen production. As a white, water‑soluble powder, it suits serums, creams, masks, and other formats, and works synergistically with ingredients like hyaluronic acid.
02
Stable Supply & Batch Consistency
Produced via synthetic biology fermentation, each batch is fully traceable and controllable, eliminating the supply risks and batch variation inherent in animal‑derived extraction.
03
Skin Rejuvenation
Reduces wrinkles, improves skin elasticity and hydration, and enhances overall skin texture and firmness.ct architecture system
04
Hair Growth Support
Shown to stimulate dermal papilla cells, promoting the anagen (growth) phase in hair follicles.
05
Applications
1.Injectable Regenerative Medicine: Mesotherapy, biorevitalization, and micro-needling solutions for skin rejuvenation, scar repair, and wound healing.
2.Advanced Topical Cosmeceuticals: High-concentration serums, creams, and masks for anti-aging, firming, and reparative skincare.
3.Professional Aesthetic Treatments: Used as a key ingredient in post-laser treatment protocols and for overall skin quality improvement.
4.Hair Loss Treatments: Formulated in scalp serums and solutions for androgenetic alopecia and hair thinning.
5.Ophthalmic & Wound Care Formulations: Under research for corneal repair and chronic wound management.
certificate
As a high-purity PDRN manufacturer and bulk supplier, LANDNUTRA holds globally authoritative certifications and a dedicated R&D & technical team specializing in high-purity Pure PDRN Powder. Catering to startups and mature brands throughout Europe and Asia - and markets beyond - our flexible OEM service converts your custom formulas into finished capsules, gummies and liquid supplements ready for market launch. Supported by our full vertical supply chain, we provide steady, compliant production tailored exclusively to your brand demands for Pure PDRN Powder and related finished goods. Reach out anytime for professional consultation and bespoke solutions; we stand by your side from initial concept to final delivery.
Email: wangjing@landnutra.com WhatsApp: +86 18092657549
Why Choose Our PDRN Powder?
Scientific Expertise
We specialize in marine-derived bioactives. Our production is backed by extensive R&D, ensuring a deep understanding of PDRN's chemistry and biology for consistent, high-grade output.
Uncompromising Quality Control
Every batch is produced under cGMP guidelines and subjected to a battery of identity, purity, potency, and safety tests. Full DMF support is available for pharmaceutical clients.
Technical & Regulatory Support
We provide comprehensive documentation (CoA, MSDS, Stability Data, TSE Statement) and dedicated support for your formulation and regulatory submission needs.
FAQ
Q: What is the source of your PDRN raw material, and how do you guarantee product safety?
A: Our PDRN is extracted from milt of wild healthy salmon sourced from standardized, compliant fisheries. Both raw materials and finished pure PDRN powder go through multi-stage strict purification and comprehensive testing to eliminate pathogens, viruses and miscellaneous impurities, fully meeting global cosmetic & supplement safety standards with reliable safety performance.
Q: Can this powder be used for injectable formulations?
A: Yes. Our PDRN powder is manufactured as an active pharmaceutical ingredient (API) suitable for injectable formulations, provided it is processed under aseptic conditions and meets all sterility and endotoxin requirements for the final product.
Q: What is the recommended dosage in formulations?
A: Dosage varies by application. Typical ranges are:
Injectable Solutions: 5.625 mg - 22.5 mg per treatment session.
Topical Skincare: 0.5% - 2.0%.
Hair Care Solutions: 0.5% - 1.5%.
Our technical team can assist with specific formulation guidance.
Q: How should the powder be stored?
A: Store in a dry, cool place (2-8°C recommended for long-term stability). The unopened container is stable for 24 months. After opening, use immediately or store under inert gas and low temperature.
Q: Do you offer PDRN in solution form?
A: Yes. We also supply sterile, ready-to-use PDRN aqueous solutions at various concentrations (e.g., 5 mg/mL, 10 mg/mL) for direct use in clinical or aesthetic settings. Please inquire separately.
Worldwide Delivery, Arranged for You
We deliver our ingredients to customers across global markets, choosing the most suitable shipping solution for every order and providing complete documentation along the way. Every delivery is handled end to end, with our team staying with the shipment until it reaches you.
Global Presence Through Industry Events
We regularly take part in international industry exhibitions to meet partners, share expertise and stay close to market trends. Details of our upcoming events are available on request.
Partnerships Built on Results
We work with brands and manufacturers across different markets and categories, supporting them from sample stage to commercial supply. Specific references and case details are shared directly with qualified customers upon request.
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