Product Description
Pure vitamin A acid powder, full name tretinoin or all-trans retinoic acid, is a potent active pharmaceutical and cosmetic ingredient. It is a yellow to light orange crystalline powder . Basically, it is the active form of vitamin A that directly regulates skin cell functions, making it a functional active ingredient central to many dermatological and anti-aging products.
It works by binding to specific retinoic acid receptors in the skin to promote cell turnover, stimulate collagen production, and normalize the shedding of dead skin cells . Different from milder retinoids like retinol that require conversion, vitamin A acid acts directly and delivers more immediate and pronounced effects. It is effective in treating acne by preventing the formation of microcomedones, improving photoaged skin by reducing fine lines and wrinkles, and even aiding in the treatment of melasma by dispersing pigment granules .
The typical addition dosage of vitamin A acid in cosmetics ranges from 0.01% to 0.1% . Too little leads to weak efficacy, while excessive dosage causes severe irritation, redness, and peeling. This product is a yellow or light orange crystalline powder with limited formula compatibility, requiring precise formulation to maintain stability. At normal use levels, it is a proven and reliable active ingredient, but it can cause skin sensitivity, especially during the initial weeks of treatment . Basic precautions, such as sun protection and avoiding use on damaged skin, are essential during use. It is a widely used and clinically validated raw material in the pharmaceutical and cosmetic industry.
Pure vitamin A acid powder Characteristics
Appearance – Yellow to light orange crystalline powder with fine particle size.
Solubility – Soluble in organic solvents (e.g., DMSO, ethanol, oils); practically insoluble in water.
Safety – Clinically proven and effective at proper dosage, but causes skin irritation, redness, and peeling during initial use (retinization). Tolerance develops over time.
Handling caution – Avoid direct contact with eyes and inhalation of raw powder. Pregnant women must strictly avoid use due to teratogenic risk.
Downside – Excessive dosage causes severe skin peeling, burning sensation, and increased sun sensitivity. Requires mandatory sun protection during use.
COA (Certificate of Analysis)
| Test Item | Specification | Typical Result |
|---|---|---|
| Purity (HPLC) | ≥98.0% | 99.2% |
| Loss on Drying | ≤0.5% | 0.2% |
| Residue on Ignition (Inorganic content) | ≤0.1% | 0.05% |
| Heavy Metals (as Pb) | ≤10 ppm | <5 ppm |
| Lead (Pb) | ≤2 ppm | <0.5 ppm |
| Arsenic (As) | ≤1 ppm | <0.2 ppm |
| Particle Size (pass 80 mesh) | 100% pass | 100% pass |
| Needle Length (microscopy) | Not specified | Crystalline powder, no significant acicular morphology |
Processing Technology
Product Benefits
Anti-aging
Stimulates collagen production, reduces fine lines and wrinkles, and improves skin firmness and elasticity.
Anti-acne
Unclogs pores, prevents microcomedone formation, and effectively treats inflammatory and non-inflammatory acne.
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Hyperpigmentation treatment
Disperses melanin granules, lightens melasma, age spots, and post-acne dark spots.
Improves skin texture
Accelerates cell turnover, smooths rough skin, and refines pore appearance.
Applications
Pharmaceuticals – Used in prescription topical drugs for treating acne vulgaris, photoaging, and hyperpigmentation disorders (e.g., melasma).
Cosmetics & Skincare – Incorporated into anti-aging serums, night creams, and corrective treatments at low concentrations (0.01%–0.05%) for over-the-counter products.
Dermatological treatments – Combined with other actives (e.g., hydroquinone, corticosteroids) in compounded formulations for stubborn pigmentary conditions.
Research & Development – Used as a reference standard in analytical testing and formulation studies for stability and efficacy validation.
Professional use only – Restricted to dermatologist-prescribed or carefully formulated products due to its potency and irritation potential; not recommended for DIY use.
Other Customizable Products (OEM / ODM)
We deliver end-to-end ODM/OEM solutions for Pure vitamin A acid powder-based formulations, transforming your concepts into market-ready products.① Cooperation Models
OEM: Reproduce your formula with strict confidentiality and consistency
ODM: Full-service formulation, development, and manufacturing
② Key ProcessAnalysis & Design: Customized solutions based on your needs
Prototyping: Sample development with advanced hydrolysis control
Production: Certified manufacturing with rigorous quality testing
Why Choose Our Pure vitamin A acid powder?
Over a Decade of Expertise: 15+ years in specialty ingredient manufacturing
Natural Purity & Quality: Sourced from high-grade silicon precursors
Transparent & Traceable: Full documentation from raw material to final product
Advanced Technology: Proprietary stabilization methods for high bioavailability
Stable Supply Assurance: Robust supply chain and inventory management
Long-term Partnership: Committed to collaborative growth and customer success
FAQ
Q:What is Tretinoin powder?
A: It is the active form of vitamin A (all‑trans‑retinoic acid, CAS 302‑79‑4). It directly binds to skin retinoic acid receptors to regulate cell growth and differentiation.
Q: What are its main uses?
Q: How does it differ from retinol?
Q: Is it allowed in cosmetics?
A:In most major markets (EU, US, China), tretinoin is not permitted in over‑the‑counter cosmetics. It is classified as a drug and requires medical supervision.
Q:What are the common side effects?
A:Redness, peeling, dryness, and increased skin sensitivity (retinization) typically occur during the first 2–4 weeks. These subside as the skin adapts.
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