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Thiamidol Powder

Thiamidol Powder

1. Specification： 98(on dried basis)
2. Sample： Sample Available
3. Test method： HPLC / Titration / ICP-MS
4. Synonyms： MAP, Magnesium ascorbyl phosphate, Vitamin C phosphate magnesium salt, Ascorbic acid phosphate magnesium salt
5. Appearance： White to off-white crystalline powder; odorless
6. Particle size： >95% pass 80 mesh
7. MOQ： 1 KG
8. Package： 1kg/foil bag (double-sealed, light‑protected), 25kgs/fiber drum
9. Certificate： HACCP, ISO 22000, HALAL, GMP, Kosher (available upon request)
10. Molecular Formula: C₁₃H₁₄N₂O₃S (typically C₆H₇MgO₉P · nH₂O)
11. CAS number: 1428450-95-6
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Description

 

Thiamidol Powder
Thiamidol, whose full name is isobutylamido thiazolyl resorcinol, is a patented high-efficiency skin brightening raw material. Simply put, this substance can fade skin pigmentation gently and effectively; it is a mainstream cosmetic whitening additive for daily skincare products, rather than a potent medical depigmenting component.
It primarily targets tyrosinase, the key enzyme for melanin synthesis. After penetrating the skin, Thiamidol inhibits tyrosinase activity to block melanin production without damaging healthy melanocytes. It delivers non-permanent but stable brightening effects, improving sun spots, acne marks, chloasma and overall skin dullness. It also prevents pigment rebound and balances uneven skin tone caused by UV damage and skin inflammation.
Its mechanism of action lies in selective inhibition of tyrosinase, with no cytotoxic damage to skin cells. It cuts off melanin generation at the initial stage, realizing dual effects of fading existing pigment and preventing new pigmentation. The brightening process takes 2-3 months to show optimal results, so long-term consistent use is required.
Thiamidol is fine white crystalline powder and nearly odorless. It dissolves easily in alcohols and cosmetic oils but is barely soluble in water, so pre-dissolution with proper solvents is needed before formulation. This powder is sensitive to light and heat and prone to activity loss, so it must be stored away from light with brown sealed containers.
In skincare formulas like serums and creams, the standard addition concentration ranges from 0.1% to 0.5% by weight. With low irritation and great skin compatibility, it fits sensitive skin formulas well. It will not cause irreversible skin depigmentation compared with medical strong whitening ingredients.

Specification: 99% (HPLC)
Sample: Sample Available
Test method: HPLC 
Synonyms: Isobutylamido Thiazolyl Resorcinol; N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)isobutyramide; dPHP-Thiamidol
MOQ: 1 KG  

Package: 1kg/foil bag (double-sealed, light‑protected), 25kg/ drum
Certificate: COA (Certificate of Analysis) available
Molecular Formula: C₁₃H₁₄N₂O₃S  

 CAS: 1428450-95-6

Product Characteristics
 
🧂

Appearance

White to off-white crystalline powder
⚗️

Purity

≥ 99% (by HPLC)
💧

Solubility

• Soluble in glycols (e.g., propylene glycol, butylene glycol)
• Soluble in organic solvents (ethanol, ethyl acetate)
• Limited solubility in water
• Heating up to 80°C can assist dissolution
⚖️

pH (5% solution)

4.0 – 6.5 (recommended formulation pH: 4.5–5.5 for optimal stability)
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Particle Size

98% passes through 80 mesh
🏭

Manufactured under GMP standards with certifications including ISO9001, ISO22000, FSSC22000, HALAL, KOSHER, and FDA-registered facility

COA (Certificate of Analysis)

Benefits of  Thiamidol Powder

  1. Inhibit melanin production fundamentally: It effectively restrains tyrosinase activity to block root melanin generation and avoid new dark spots.
  2. Fade various stubborn pigmentation: It efficiently lightens acne marks, sun spots and melasma to fix uneven facial skin tone steadily.
  3. Ultra-gentle with low skin irritation: It features mild whitening performance and brings no redness or stinging for sensitive skin.
  4. Prevent pigmentation rebound effectively: It offers long-term whitening effects and stops dark spots from recurring after fading completely.
  5. Perfect compatibility with skincare actives: It mixes stably with most common skincare ingredients to enhance overall brightening effects.
  6. Safe for long-term daily skincare use: It will not damage the skin barrier and fits daily long-term brightening skincare routines safely.

Application Fields

  1. Brightening & Spot-fading Skincare Products: Applied in essence, cream and serum to fade acne marks, sun spots and improve dull skin.
  2. Sensitive Skin Whitening Products: Added into mild skincare formulas, realizing gentle whitening without hurting fragile skin barrier.
  3. Daily Anti-pigmentation Maintenance Products: Used in long-term daily skincare to prevent melanin deposition and avoid pigment rebound.

Production Process

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Product Quality Advantage

  1. Ultra high purity of raw material powder
  1. Gentle formula with minimal skin irritation
  1. Excellent molecular stability in storage
  1. Fast and complete solubility in solvents
  1. Great compatibility with skincare ingredients
  1. Professional and rigorous quality testing
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Quality Control LabAnnual Capacity: 1,500 Tons | 15+ years of cosmetic active ingredient expertise

Professional ODM/OEM Services

We provide full OEM/ODM manufacturing for finished products featuring MAP as the key active ingredient.

Finished Skincare Products

  1. Brightening facial serum and essence
  2. Spot removal face cream and lotion
  3. Repairing mask for dull skin

Formulation Support

  1. Provide standard formula reference
  2. Offer ingredient matching guidance
  3. Solve formula stability problems

Additional Services

  1. Free product sample provision
  2. Complete quality inspection report
  3. Professional technical after-sales support

FAQ

Q1:  What is the main function of thiamidol powder?
A: It inhibits melanin and fades various facial pigmentation gently.
Q2: Is it suitable for sensitive skin formulas?
A: Yes, it is low-irritation and friendly to sensitive skin.
Q3: Can it be mixed with other skincare actives?
A: 
It has good compatibility with most common cosmetic ingredients.
Q4: What finished products can add this ingredient?
A: Serum, cream, lotion, facial mask and other whitening skincare.
Q5: Will pigmentation rebound after long-term use?
A: It can effectively prevent melanin rebound for long-term effect.
Q6: Can you provide formula technical support?
A: Yes, we offer full formula guidance and related technical service.

 

Test ItemSpecification (Cosmetic Grade)Test ResultConclusion
Appearance
White crystalline powder, odorless
ConformsPass
Assay (HPLC)
≥99.0%
99.62%Pass
Free Ascorbic Acid≤0.05%0.01%Pass
pH (5% solution)4.5-6.55.2Pass
Lead (Pb)≤1.0 ppm<0.1 ppmPass
Total Plate Count≤1,00 cfu/g<10 cfu/gPass
E. Coli / SalmonellaNegativeNegativePass

 

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