Description

Citrulline Malate Powder

Citrulline Malate (CM) is an organic salt formed by the combination of the non-essential amino acid L-citrulline and L-malic acid (malate), an intermediate in the citric acid (Krebs) cycle. Its name is derived from Citrullus vulgaris (watermelon), the primary dietary source of citrulline, while malate is abundant in apples and grapes.

💨 The "Synergistic Nitric Oxide Amplifier": L-citrulline serves as a potent precursor to L-arginine, bypassing first‑pass hepatic metabolism to effectively elevate plasma arginine levels, thereby stimulating nitric oxide (NO) production and promoting vasodilation. The malate component adds a second layer of benefit: as a Krebs cycle intermediate, it may enhance ATP production and support energy metabolism during high‑intensity exercise.

Proven Anti‑Fatigue Properties: Citrulline malate was originally developed as a pharmaceutical drug (STIMOL®) for the treatment of asthenia and fatigue, with clinical studies demonstrating its ability to stimulate hepatic ureogenesis and protect against acidosis and ammonia accumulation.

📐 Verified 2:1 Ratio: Our citrulline malate is manufactured to a verified 2:1 L‑citrulline:malate ratio, ensuring consistent potency. Commercial products may vary in their ratios (1:1 or 2:1) - our product meets the research‑supported standard.

Specification: 98.0% – 101.0% (as L-Citrulline DL-Malate, 2:1 ratio)
Sample: Sample Available
Test method: HPLC / Titration / USP method
Synonyms: L-Citrulline DL-malate, Stimol, Citrulline malate salt
MOQ: 1 KG | Package: 1kg/foil bag, 25kgs/drum
Certificate: HACCP, ISO 22000, HALAL, GMP, Kosher (available upon request)
Molecular Formula: C₆H₁₃N₃O₃·C₄H₆O₅ | Molecular Weight: 309.27 g/mol | CAS: 70796-17-7

Product Characteristics

🧂

Appearance

White crystalline powder; almost odorless.

⚗️

Purity

98.0% – 101.0% - verified 2:1 ratio.

💧

Solubility

Freely soluble in water - ideal for beverages.

⚖️

Composition

~67% L-Citrulline + ~33% Malate (verified 2:1 ratio).

📏

Particle Size

>95% pass 80 mesh.

🏭

GMP Manufacturing

Advanced synthesis with full traceability.

COA (Certificate of Analysis)

Benefits of Citrulline Malate Powder

01Enhanced Nitric Oxide Production

L-citrulline elevates plasma arginine levels more effectively than direct arginine supplementation, supporting NO‑mediated vasodilation and improved blood flow to active musculature.

02Improved Exercise Performance & Endurance

Studies demonstrate that citrulline malate supplementation enhances upper body muscular endurance and increases repetitions to failure during resistance training. Improves both aerobic and anaerobic exercise performance.

03Ammonia Clearance & Fatigue Reduction

Citrulline facilitates ammonia elimination via the urea cycle, helping reduce acidosis and muscle fatigue during intense exercise.

04Enhanced ATP Production (Malate Effect)

The malate component contributes to the Krebs cycle and the malate‑aspartate shuttle, potentially increasing the rate of ATP production and supporting energy metabolism.

05Reduced Muscle Soreness & Recovery

CM may improve muscle recovery by enhancing nutrient delivery and waste product removal, potentially reducing delayed‑onset muscle soreness (DOMS).

06Verified 2:1 Ratio

Manufactured to a verified 2:1 L‑citrulline:malate ratio - the research‑supported standard for potency and efficacy. Quality control verified.

Application Fields

Dietary Supplements (Hero Application): Pre‑workout & pump formulas (6–8 g), capsules & tablets, powdered drink mixes, gummies & chewables, amino acid blends.
Pharmaceuticals: API for drug formulations (fatigue management, asthenia treatment, cardiovascular support).
Food & Nutrition: Functional foods & beverages, protein bars, protein shakes.
OEM Finished Products: NO booster capsules, pre‑workout powder sticks, endurance gummies, protein bars, liquid drops - full custom manufacturing available.

Production Process

Production process of Citrulline Malate

Process: L-Citrulline (fermentation‑derived) + DL‑malic acid (2:1 molar ratio) → salt formation → recrystallization → activated carbon treatment → gentle drying → milling → sieving → packaging.

Product Quality Advantage

98.0% – 101.0% Purity – USP grade available.

Verified 2:1 Ratio – Research‑supported potency.

Fermentation‑Derived – Non‑animal, sustainable, vegan.

Low Heavy Metals – Pb <2 ppm.

Excipient‑Free – 100% active ingredient.

cGMP Certified – Full traceability and documentation.

Annual Capacity: 1,500 Tons | 15+ years of ingredient expertise

Professional ODM/OEM Services

We provide full OEM/ODM manufacturing for finished products using Citrulline Malate as the active ingredient - from concept to commercial delivery, all under one roof.

① Finished Dosage Forms
Capsules: 500 mg, 750 mg, 1000 mg; vegetarian/gelatin; custom bottle/blister.
Tablets: Direct compression; round/oval; debossing.
Chews & Gummies: Natural/artificial flavors; sugar‑free options.
Powder Blends: Stick packs, tubs; with L‑Arginine, Beta‑Alanine, caffeine.
Liquids: Solutions, ready‑to‑drink.
Bars: Protein bars, snack bars.

② Combination Options
Citrulline Malate + L-Arginine (NO cycle synergy), Citrulline Malate + Beta‑Alanine (endurance), Citrulline Malate + Caffeine (pre‑workout energy).

③ Additional Services
Flavor development, third‑party certification (NSF, Informed Sport, Kosher, HALAL), stability testing, regulatory documentation.

📧 Email: wangjing@landnutra.com

📱 WhatsApp: +86 18092657549

All backed by LANDNUTRA's quality assurance - full GMP, Halal, Kosher, COA certification and complete traceability from sourcing to finished product.

Export Certificates

Certificates HACCP ISO HALAL GMP Kosher

Why choose us

XI'AN LANDNUTRA CO., LTD. – Your Trusted Manufacturer of Functional Ingredients. Rooted in Quality, Driven by Expertise, Committed to Health and Excellence.

Strong Production Capability: Annual capacity 1,500 tons. 15+ years experience, own facility.
Leading Service: ONE-STOP OEM/ODM from pre-sales to after-sales.
Quality Assurance: CQC-certified enterprise, purity embedded in every process.
Broad Market: Botanical Extracts, Cosmetic Ingredients, Functional Ingredients.

15+ years of experience in functional ingredients and amino acid manufacturing. Vertically integrated from raw material sourcing to finished goods manufacturing. Batch‑specific COA including ratio verification, heavy metals, and microbiological limits. Technical support for formulation and stability.

FAQ

Q1: What is the difference between L-Citrulline and Citrulline Malate?

A: Citrulline Malate is an organic salt formed by combining L‑citrulline with malic acid (malate). While L‑citrulline alone supports NO production, the malate component adds potential benefits by serving as a Krebs cycle intermediate, which may enhance ATP production and energy metabolism during intense exercise.

Q2: What is the recommended dosage?

A: Typical acute doses range from 6 to 8 g of citrulline malate. Chronic supplementation studies have used 12 g/day (2:1 ratio, providing approximately 8 g of L‑citrulline). Doses up to 15 g/day are considered safe and well‑tolerated.

Q3: What is the optimal citrulline:malate ratio?

A: Common ratios include 1:1 and 2:1. The 2:1 ratio (approximately 67% L‑citrulline, 33% malate) is widely used in research and commercial products. Our product is verified to meet its specified 2:1 ratio.

Q4: Does citrulline malate improve exercise performance?

A: Research indicates that chronic citrulline supplementation enhances upper body muscular endurance and post‑exercise NOX response to resistance training. Studies have demonstrated increased repetitions to failure and improved performance in both aerobic and anaerobic exercise modalities.

Q5: Is citrulline malate safe?

A: Citrulline malate has been extensively studied and is considered safe at recommended doses. It was originally developed as a pharmaceutical drug (STIMOL®) for fatigue management. No significant adverse effects have been reported at typical dosages.

Q6: Is citrulline malate vegan?

A: Yes. Our citrulline malate is produced via plant‑based fermentation. It does not contain any animal‑derived components.

Q7: What is the shelf life?

A: 24 months in original sealed container under cool, dry conditions (≤25°C, ≤60% RH). Powder stable for 3 years at -20°C.

Q8: Can citrulline malate be used in clear liquid supplements?

A: Yes. It is freely soluble in water, making it suitable for clear liquid formulations and ready‑to‑drink beverages.

Q9: Can citrulline malate be combined with L-Arginine?

A: Yes - this is a common combination. Citrulline provides sustained arginine availability, while L-Arginine provides an immediate NO boost. They are often stacked together in pre‑workout formulations.

Q10: What is the difference between citrulline malate and pure L-citrulline?

A: Citrulline malate contains about 67% L-citrulline and 33% malate. Pure L-citrulline is 100% citrulline. The malate in CM provides additional ATP support via the Krebs cycle.

Q11: Can citrulline malate help with fatigue?

A: Yes. Citrulline malate was originally developed as a pharmaceutical (STIMOL®) for asthenia and fatigue. It supports ammonia clearance and reduces acidosis during exercise.

Q12: Is citrulline malate stable in solution?

A: Yes, it is freely soluble and stable in aqueous solutions under proper conditions. Solutions should be protected from heat and prolonged exposure to light.

Test Item	Specification (USP Grade)	Test Result	Conclusion
Appearance	White crystalline powder	Conforms	Pass
Assay (HPLC)	98.0% – 101.0%	99.5%	Pass
L-Citrulline Content	65.0% – 68.0% (2:1 ratio)	66.8%	Pass
Malate Content	32.0% – 35.0%	33.2%	Pass
Specific Optical Rotation	+24.5° to +26.8°	+25.6°	Pass
Loss on Drying	≤0.5%	0.2%	Pass
Heavy Metals (as Pb)	≤10 ppm	<2 ppm	Pass
Total Plate Count	≤1,000 cfu/g	<100 cfu/g	Pass
E. Coli / Salmonella	Negative	Negative	Pass

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