Description

Vitamin K2 (MK-7) Powder

Vitamin K2 (MK-7) is a fat-soluble vitamin and the most bioavailable form of vitamin K2, belonging to the menaquinone family. It is an essential nutrient that plays a critical role in calcium metabolism, bone health, and cardiovascular protection.

🦴 The "Bone and Artery Guardian": MK-7 activates two key vitamin K-dependent proteins: Osteocalcin (directs calcium into bone tissue, supporting bone mineralization) and Matrix Gla-Protein (MGP) (prevents calcium deposition in blood vessels, protecting against vascular calcification). This unique "calcium director" function makes MK-7 essential for both skeletal health and cardiovascular protection.

Extended Half-Life Advantage: Unlike Vitamin K1 or other K2 forms (such as MK-4), MK-7 has a significantly longer half-life of approximately 3 days, allowing for once-daily dosing and sustained biological activity.

Natural & Fermentation-Derived: Our MK-7 is produced via fermentation using Bacillus subtilis, yielding a high-purity, natural-form menaquinone that mirrors the compound found in fermented foods like natto.

🌡️ Storage Note: MK-7 is highly sensitive to light and heat. Store in the original sealed container, protected from light, at 2–8°C (short-term) or -20°C (long-term).

⚠️ Important Safety Note: Vitamin K2 can interfere with anticoagulant medications (such as warfarin). Patients taking blood thinners should consult their healthcare provider before supplementation.

Specification: ≥97.0% – 98.0% (HPLC, on dried basis)
Sample: Sample Available
Test method: HPLC / LC-MS / USP method
Synonyms: Menaquinone-7, MK-7, Vitamin K2(35), Menaquinone 7
MOQ: 1 KG | Package: 1kg/foil bag (light-protected), 25kgs/drum
Certificate: HACCP, ISO 22000, GMP, HALAL (available upon request), Kosher (available upon request)
Molecular Formula: C₄₆H₆₄O₂ | CAS: 2124-57-4

Product Characteristics

🧂

Appearance

Pale yellow to white crystalline powder; odorless.

⚗️

Purity

≥97% – 98% (HPLC) - high-purity menaquinone.

⏳

Half-Life

~3 days - sustained biological activity, once-daily dosing.

💧

Solubility

Fat-soluble; soluble in oils and organic solvents; insoluble in water.

🔬

Source

Fermentation-derived (Bacillus subtilis) - natural, vegan.

🏭

GMP Manufacturing

Controlled fermentation with full traceability.

COA (Certificate of Analysis)

Benefits of Vitamin K2 (MK-7) Powder

01Bone Health & Osteoporosis Prevention

MK-7 activates osteocalcin, a protein that binds calcium into the bone matrix, supporting bone mineralization and reducing fracture risk. Clinical studies demonstrate increased bone mineral density in postmenopausal women.

02Cardiovascular Protection

MK-7 activates Matrix Gla-Protein (MGP), which prevents calcium deposition in arterial walls and protects against vascular calcification. Supports arterial elasticity and overall cardiovascular health.

03Superior Bioavailability

MK-7 has an extended half-life of approximately 3 days, allowing for once-daily dosing and sustained biological activity - significantly longer than other vitamin K forms.

04Calcium Homeostasis - The "Calcium Director"

MK-7 ensures calcium is directed to the bones rather than accumulating in soft tissues and blood vessels - supporting both skeletal and vascular health.

05Fermentation-Derived & Natural

Produced via Bacillus subtilis fermentation - yielding a high-purity, natural-form menaquinone that mirrors the compound found in fermented foods like natto.

06Pharmaceutical & Clinical Applications

MK-7 is being investigated in pharmaceutical compositions for improving cardiovascular calcification, particularly in patients taking statins.

Application Fields

Dietary Supplements (Hero Application): Capsules & softgels (45–300 mcg), tablets, powder blends & stick packs, gummies & chewables, multivitamin & mineral blends (with Vitamin D3 and Calcium).
Functional Foods & Beverages: Fortified beverages, nutrition bars.
Cosmetics & Personal Care: Skin care (face cream up to 0.389%, hand cream up to 0.277%, body lotion up to 0.076%).
Pharmaceuticals: API for compositions targeting cardiovascular calcification and bone health.
OEM Finished Products: Softgels, bone support formula, cardiovascular powder sticks, gummies, custom bone health blends - full custom manufacturing available.

Production Process

Production process of Vitamin K2 (MK-7)

Process: Bacillus subtilis fermentation → solvent extraction → chromatography purification → recrystallization → gentle drying → standardization → milling → sieving → light‑protected packaging.

Product Quality Advantage

≥97% – 98% Purity – High-purity menaquinone.

~3 Day Half-Life – Sustained biological activity.

Fermentation-Derived – Natural, vegan, non-GMO.

Low Heavy Metals – Pb <0.3 ppm.

Light-Protected Packaging – Ensures stability.

cGMP Certified – Full traceability and documentation.

Annual Capacity: 1,500 Tons | 15+ years of lipid-soluble vitamin expertise

Professional ODM/OEM Services

We provide full OEM/ODM manufacturing for finished products using Vitamin K2 (MK-7) as the active ingredient - from concept to commercial delivery, all under one roof.

① Finished Dosage Forms
Capsules & Softgels: 45 mcg, 90 mcg, 180 mcg, 300 mcg; custom carrier oils.
Tablets: Direct compression; round/oval; debossing.
Chews & Gummies: Custom flavors, sugar‑free options.
Powder Blends: Stick packs, tubs; with Vitamin D3, Calcium, Magnesium.
Cosmetics: Serums, creams, lotions (subject to regulatory limits).
Bars: Protein bars, snack bars.

② Combination Options
MK-7 + Vitamin D3 + Calcium (bone health), MK-7 + Omega-3 (cardiovascular), MK-7 + Magnesium (mineral support).

③ Additional Services
Flavor development, third‑party certification (NSF, Informed Sport, Kosher, HALAL), stability testing (light protection), regulatory documentation.

📧 Email: wangjing@landnutra.com

📱 WhatsApp: +86 18092657549

All backed by LANDNUTRA's quality assurance - full GMP, Halal, Kosher, COA certification and complete traceability from sourcing to finished product.

Export Certificates

Certificates HACCP ISO GMP Halal Kosher

Why choose us

XI'AN LANDNUTRA CO., LTD. – Your Trusted Manufacturer of Functional Ingredients. Rooted in Quality, Driven by Expertise, Committed to Health and Excellence.

Strong Production Capability: Annual capacity 1,500 tons. 15+ years experience, own facility.
Leading Service: ONE-STOP OEM/ODM from pre-sales to after-sales.
Quality Assurance: CQC-certified enterprise, purity embedded in every process.
Broad Market: Botanical Extracts, Cosmetic Ingredients, Functional Ingredients.

15+ years of experience in functional ingredients and lipid-soluble vitamins. Vertically integrated from raw material sourcing to finished goods manufacturing. Batch‑specific COA including HPLC assay, heavy metals, loss on drying, and microbial limits. Technical support for formulation and stability.

FAQ

Q1: What is the difference between Vitamin K2 (MK-7) and Vitamin K1?

A: Vitamin K1 is primarily involved in blood clotting, while Vitamin K2 (MK-7) is essential for calcium metabolism - directing calcium to bones and away from arteries. MK-7 also has a significantly longer half-life (~3 days) compared to K1 (~1 hour).

Q2: What is the recommended daily dose?

A: Typical supplemental doses range from 45 mcg to 300 mcg per day. Clinical studies have used doses of 800 mcg/day for bone health benefits. Always consult a healthcare provider for personalized recommendations.

Q3: How should MK-7 powder be stored?

A: Store in the original sealed container, protected from light, under cool, dry conditions (2–8°C or -20°C for long-term storage). MK-7 is highly sensitive to light and heat.

Q4: Is MK-7 safe?

A: Vitamin K2 (MK-7) has an excellent safety profile and is considered safe at recommended doses. No significant adverse effects have been reported in clinical studies.

Q5: Is MK-7 vegan?

A: Yes. Our MK-7 is produced via bacterial fermentation (Bacillus subtilis). It does not contain any animal-derived components.

Q6: What is the shelf life?

A: 24 months in original sealed container under recommended storage conditions. Stability is enhanced by light-protected packaging and refrigeration.

Q7: Can MK-7 be used in clear liquid supplements?

A: No. MK-7 is fat-soluble and insoluble in water. It is best suited for softgels, capsules, tablets, and oil-based formulations. For aqueous applications, use emulsified or cyclodextrin-complexed forms.

Q8: Does MK-7 interact with blood thinners?

A: Yes. Vitamin K2 can interfere with anticoagulant medications (such as warfarin). Patients taking blood thinners should consult their healthcare provider before supplementation.

Q9: Can MK-7 be combined with Vitamin D3 and Calcium?

A: Yes - this is a classic and synergistic combination. Vitamin D3 promotes calcium absorption, and MK-7 directs that calcium to bones rather than arteries. Together they support comprehensive bone and cardiovascular health.

Q10: What is the difference between MK-7 and MK-4?

A: MK-4 has a short half-life (~1–2 hours) and requires multiple daily doses. MK-7 has a half-life of ~3 days, allowing for once-daily dosing and more sustained biological activity. MK-7 is also more bioavailable and is the preferred form for supplementation.

Q11: Can MK-7 be used in cosmetics?

A: Yes - MK-7 is used as a skin protectant and antioxidant in various cosmetic formulations. Maximum recommended use levels vary: face cream up to 0.389%, hand cream up to 0.277%, body lotion up to 0.076% (excluding sprays and powders).

Q12: Is MK-7 suitable for gummies?

A: MK-7 is fat-soluble and requires oil-based formulation. Gummies can be formulated with emulsified or cyclodextrin-complexed MK-7 for oil-based gummies. Our formulation team can advise on stability and formulation.

Test Item	Specification (≥98% Grade)	Test Result	Conclusion
Appearance	Pale yellow to white crystalline powder	Conforms	Pass
Assay (HPLC)	≥98.0%	98.3%	Pass
Identification (HPLC)	Conforms to reference standard	Conforms	Pass
Loss on Drying	≤0.5%	0.2%	Pass
Lead (Pb)	≤1 ppm	<0.3 ppm	Pass
Total Plate Count	≤1,000 CFU/g	<100 CFU/g	Pass
E. Coli / Salmonella	Negative	Negative	Pass

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