Description

Zinc Orotate Powder

Zinc Orotate is a coordination complex in which one zinc(II) ion (Zn²⁺) is chelated by two molecules of orotic acid (pyrimidinecarboxylic acid). Orotic acid - also known as vitamin B₁₃ (though not officially recognized as a vitamin in most jurisdictions) - is a naturally occurring intermediate in the pyrimidine nucleotide biosynthesis pathway. The rationale for using zinc orotate as a dietary supplement is based on the hypothesis that the orotate ligand may facilitate cellular uptake of zinc via nucleoside/nucleotide transport mechanisms, potentially enhancing intracellular bioavailability.

Chemical Context: Why Orotate? Orotic acid is a pyrimidine derivative bearing a carboxyl group that can coordinate metal ions. In vivo, orotate is converted to orotidine‑5′-monophosphate (OMP) and subsequently to UMP, a precursor for all pyrimidine nucleotides. Proponents argue that the orotate‑zinc complex may be transported into cells via pyrimidine transporters - a "hitchhiker" mechanism.

Structural Chemistry: Each orotate ligand coordinates zinc via one oxygen atom of the carboxylate group and potentially the pyrimidine ring nitrogen. The common commercial form is the dihydrate: Zn(C₅H₃N₂O₄)₂·2H₂O. Elemental zinc content is approximately 15% by weight.

Comparison with Other Zinc Forms

Property	Zinc Orotate	Zinc Picolinate	Zinc Bisglycinate	Zinc Gluconate
Elemental Zn content	~15%	~21%	~21–22%	~14%
Solubility in water	Low	Low	Moderate–High	High
Chelation type	Pyrimidine carboxylate	Aromatic chelate	Amino acid chelate	Salt (non‑chelated)
Clinical evidence base	Limited	Moderate	Moderate–Good	Good

⚠️ EU Regulatory Notice: Zinc orotate is not listed in Annex II of Regulation (EC) No 1170/2009 as a permitted zinc compound for food supplements in the European Union. This product is not intended for sale or distribution in the EU. Contact us for permitted zinc forms for EU markets.

Specification: 98.0% – 102.0% (on dried basis)
Sample: Sample Available
Test method: HPLC / ICP-MS / Titration / USP method
Synonyms: Zinc orotate dihydrate, Zinc(II) orotate, Orotic acid zinc salt, Zn(Oro)₂
MOQ: 1 KG | Package: 1kg/foil bag, 25kgs/drum
Certificate: HACCP, ISO 22000, GMP (HALAL status varies by batch; contact for details)
Molecular Formula: Zn(C₅H₃N₂O₄)₂·2H₂O | CAS: 68399-99-5

Product Characteristics

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Appearance

Fine, free-flowing white to off-white crystalline powder; odorless.

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Elemental Zinc Content

14.5% – 16.5% (approximately 15% in dihydrate form).

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Solubility

Low in water (0.3–0.8 g/L), but readily soluble in gastric acid.

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Chelate Stability

Stable chelate structure; dihydrate form is the common commercial form.

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Particle Size

>95% pass 80 mesh (standard); micronized available.

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GMP Manufacturing

Produced in certified facilities with controlled chelation.

COA (Certificate of Analysis)

Benefits of Zinc Orotate Powder

01Essential Zinc Supplementation

Zinc is required for immune function, enzymatic catalysis (over 300 zinc-dependent enzymes), DNA and protein synthesis, wound healing, and normal growth and development.

02Nucleoside Transporter "Hitchhiker" Hypothesis

The theoretical advantage: orotate may facilitate cellular uptake via pyrimidine (nucleoside) transporters, potentially enhancing intracellular zinc delivery.

03Dual Benefit: Zinc + Pyrimidine Precursor

Orotic acid is a precursor for uridine monophosphate (UMP) and all pyrimidine nucleotides - supporting nucleotide synthesis alongside zinc replenishment.

04Good Tolerability

Zinc orotate is generally well tolerated, with fewer reports of nausea compared to inorganic zinc salts like zinc sulphate.

05Endogenous Metabolite

Orotic acid is a naturally occurring compound (present in milk), giving the supplement a "natural" positioning for certain market segments.

06Antioxidant Defense

Zinc is a cofactor for copper‑zinc superoxide dismutase (CuZnSOD), one of the body's primary antioxidant enzymes.

Application Fields

Dietary Supplements (Premium / Specialty Niche): Capsules (10–20 mg elemental zinc), tablets, chewable tablets, powder blends.
Multivitamin / Multimineral Blends: Compatible with most vitamins and minerals; careful with copper, calcium, iron competition.
Clinical Nutrition (Niche): Used in certain complementary and alternative medicine protocols.
Sports Nutrition (Niche): Occasionally included in premium recovery formulas leveraging theoretical nucleotide support.
OEM Finished Products: Capsules, tablets, chews, liquid suspensions, RTD drinks, bars - full custom manufacturing available.

Production Process

Production process of Zinc Orotate

Product Quality Advantage

≥98% Purity – High-quality chelated zinc.

15% Elemental Zinc – Dihydrate form.

Low Heavy Metals – Pb <0.3 ppm, As <0.5 ppm, Cd <0.2 ppm.

Low Free Orotic Acid – ≤0.5% typical.

Excellent Dry Stability – 24 months shelf life.

cGMP Certified – Full traceability and documentation.

Annual Capacity: 1,500 Tons | 15+ years of chelated mineral manufacturing

Professional ODM/OEM Services

We provide full OEM/ODM manufacturing for finished products using zinc orotate as the active ingredient.

① Finished Dosage Forms
Capsules: Sizes 0–00; 10 mg, 15 mg, 20 mg elemental zinc; vegetarian/gelatin; bottle or blister.
Tablets: Direct compression or wet granulation; round/oval; debossing; coated/uncoated.
Chews: Soft‑chew or gummy; fruit flavors; sugar‑free options; taste masking important.
Liquid Zinc Orotate: Suspension format; single‑serve shots or multi‑dose bottles.
RTD Drinks: Pre‑mixed beverages; requires suspension stabilizers; flavored (berry, citrus, fruit punch).
Bars: Protein bars, snack bars; zinc orotate blended into dough.

② Additional Services
Flavor development, sweetener selection, third‑party certification (NSF, Informed Sport, Kosher, HALAL), stability studies, regulatory documentation.

Export Certificates

Certificates HACCP ISO GMP

Why choose us

XI'AN LANDNUTRA CO., LTD. – Your Trusted Manufacturer of Antioxidant & Functional Ingredients. Rooted in Quality, Driven by Expertise, Committed to Health and Excellence.

Strong Production Capability: Annual capacity 1,500 tons. 15+ years experience, own facility.
Leading Service: ONE-STOP OEM/ODM from pre-sales to after-sales.
Quality Assurance: CQC-certified enterprise, purity embedded in every process.
Broad Market: Botanical Extracts, Cosmetic Ingredients, Functional Ingredients.

15+ years of chelated mineral manufacturing. cGMP‑certified facilities. Full in‑house OEM/ODM capabilities for capsules, tablets, chews, liquids, RTD drinks, and bars. Regulatory documentation support for markets where zinc orotate is permitted (US, Asia, Latin America). Batch‑specific COA including zinc assay, heavy metals, and free orotic acid. Technical support for formulation, especially regarding mineral‑mineral interactions.

FAQ

Q1: Is zinc orotate better absorbed than other forms of zinc?

A: The evidence does not support claims of superior absorption. Some small studies suggest good bioavailability, but large‑scale comparative trials are lacking. The theoretical "nucleoside transporter" mechanism is plausible but unproven in humans. Zinc orotate is not definitively better absorbed than zinc bisglycinate, zinc picolinate, or even zinc sulphate when taken between meals.

Q2: What is orotic acid, and why is it in this supplement?

A: Orotic acid is a naturally occurring pyrimidine precursor, involved in the synthesis of uridine monophosphate (UMP) and subsequently all pyrimidine nucleotides. It is present in milk (hence the name from Greek oros, whey). The idea is to pair zinc with a ligand that may facilitate cellular uptake via nucleoside transport systems.

Q3: Is zinc orotate legal in the European Union?

A: No. Zinc orotate is not listed as a permitted zinc compound for food supplements in EU Regulation 1170/2009. It cannot be sold as a dietary supplement in the EU. If targeting the EU market, use permitted forms: zinc citrate, zinc gluconate, zinc bisglycinate, zinc picolinate, zinc oxide, or zinc sulphate.

Q4: What is the typical dose of zinc orotate?

A: For supplementation: 10–30 mg elemental zinc per day. Convert to zinc orotate powder: divide by 0.15 (15% Zn). Example: 15 mg Zn = 100 mg zinc orotate. Upper tolerable limit (adults): 40 mg/day elemental zinc.

Q5: Does zinc orotate cause nausea like zinc sulphate?

A: Zinc orotate is generally well tolerated and less likely to cause nausea, especially when taken on an empty stomach. However, very high doses or individual sensitivity can still cause gastrointestinal distress.

Q6: Why is zinc orotate more expensive than other zinc forms?

A: Orotic acid is more expensive to produce than picolinic acid, glycine, or gluconic acid. Additionally, zinc orotate has lower zinc density (15% vs. 21–36% for other forms), so more powder is required per dose, further increasing cost.

Q7: Can zinc orotate be used in clear liquid supplements?

A: No. Zinc orotate has low water solubility and forms a suspension, not a clear solution. For clear solutions, use zinc gluconate, zinc sulphate, or zinc bisglycinate.

Q8: Is zinc orotate suitable for vegans?

A: Yes. Zinc orotate is synthesized from orotic acid and a zinc source. No animal products are involved. (Check HALAL status for specific batches if required.)

Q9: Does zinc orotate interfere with antibiotics?

A: Zinc can reduce absorption of tetracyclines and quinolones. Separate doses by at least 2–3 hours. This applies to all zinc supplements. Consult a healthcare provider if taking prescription medications.

Q10: What is the shelf life of zinc orotate powder?

A: 24 months in original sealed container under cool, dry conditions (≤25°C, ≤60% RH). Once opened, use within 12 months.

Q11: Should I choose zinc orotate over zinc bisglycinate or zinc picolinate?

A: For most applications, no. Zinc bisglycinate and zinc picolinate have better solubility (bisglycinate) or higher zinc density (both), are less expensive, and have more clinical evidence. Zinc orotate is a specialty product for specific brand positioning emphasizing the orotate ligand's theoretical role in nucleotide metabolism.

Q12: Is zinc orotate safe for long‑term use?

A: Yes, at recommended doses (10–30 mg elemental zinc/day). Long‑term high doses (>40 mg/day) can cause copper deficiency, as with any zinc supplement. Monitor copper status if using higher doses or combine with copper (1–2 mg/day).

Test Item	Specification (High-Purity Grade)	Test Result	Conclusion
Appearance	White to off-white crystalline powder	Conforms	Pass
Assay (as Zn(C₅H₃N₂O₄)₂·2H₂O)	98.0% – 102.0%	99.3%	Pass
Zinc Content (as Zn)	14.5% – 16.5%	15.6%	Pass
Orotic Acid Content	82.0% – 85.0%	83.8%	Pass
Water Content (KF)	7.0% – 9.5%	8.5%	Pass
pH (1% suspension)	5.0 – 6.5	5.8	Pass
Lead (Pb)	≤1.0 ppm	<0.3 ppm	Pass
Arsenic (As)	≤1.0 ppm	<0.5 ppm	Pass
Cadmium (Cd)	≤1.0 ppm	<0.2 ppm	Pass
Free Orotic Acid	≤1.0%	0.5%	Pass
Total Plate Count	≤1,000 cfu/g	<100 cfu/g	Pass
E. Coli / Salmonella	Negative	Negative	Pass

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