introduction
Spermidine (CAS 124-20-9) is a naturally occurring polyamine found in virtually every living cell, where it acts as a master regulator of autophagy - the body's cellular "recycling and renewal" system that clears damaged proteins, organelles and cellular debris. Endogenous spermidine levels decline steadily with age, and this decline is closely linked to reduced cellular renewal capacity.
Our Natural Spermidine is a 100% plant-derived extract obtained from wheat germ (Triticum aestivum) - the richest known natural food source of spermidine - using gentle water/ethanol extraction and physical purification. No chemical synthesis, no synthetic monomers, no fermentation additives.
The natural wheat-germ matrix delivers spermidine together with its natural co-actives - other polyamines (spermine, putrescine), B-vitamins and plant bioactives - providing a full-spectrum profile that isolated synthetic spermidine cannot replicate.

Why Natural - The Natural Advantage
1.The richest natural source: wheat germ is the highest known dietary source of spermidine. Nature already concentrates it there - our job is gentle extraction, not invention.
2.Full-spectrum advantage: the natural extract retains co-active polyamines and plant bioactives (B-vitamins, polyphenols) that work synergistically - a "matrix effect" that a synthetic monomer cannot offer.
3.Clean-label and vegan: can be labeled "Natural", "Plant-Based", "Non-GMO" and "Vegan-Friendly" - impossible for chemically synthesized spermidine.
4.Gentle, food-grade processing: water/ethanol extraction preserves the natural polyamine profile without harsh chemical steps.
5.Recognizable, sustainable origin: wheat germ is a food-grade by-product of milling - an honest, sustainable, plant-derived story consumers understand.
6.Naturally limited supply: spermidine exists at very low concentrations in wheat germ, so genuine natural extracts require large raw-material volumes and careful multi-stage purification - a natural rarity that premium clean-label brands can build on.
COA
|
Item |
Specification |
Result |
Method |
|
Appearance |
Off-white to light-yellow fine powder |
Conforms |
Visual |
|
Identification |
Conforms to reference standard |
Conforms |
HPLC / GC |
|
Spermidine Content |
1.0% |
2.8% |
HPLC / GC |
|
Loss on Drying |
≤5.0% |
2.6% |
Gravimetric |
|
Heavy Metals (Total) |
≤10 ppm |
<5 ppm |
ICP / AAS |
|
Lead (Pb) |
≤3 mg/kg |
<1 ppm |
ICP-MS / AAS |
|
Arsenic (As) |
≤2 mg/kg |
<1 ppm |
ICP-MS / AAS |
|
Cadmium (Cd) |
≤1 mg/kg |
<0.5 ppm |
ICP-MS / AAS |
|
Mercury (Hg) |
≤0.1 mg/kg |
<0.05 ppm |
ICP-MS / AAS |
|
Residual Solvents (ethanol) |
Conforms |
Conforms |
GC |
|
Total Plate Count |
≤1,000 cfu/g |
<10 CFU/g |
Plate count |
|
Yeast & Mold |
≤100 cfu/g |
<10 CFU/g |
Plate count |
|
E. coli / Salmonella |
Negative / Negative |
Negative / Negative |
Plate count / PCR |
|
Storage / Shelf Life |
Sealed, cool & dry, protected from light & heat; 24 months |
- |
- |

1.Induces autophagy through well-documented mechanisms (inhibition of the EP300 acetyltransferase and activation of TFEB), supporting cellular cleanup, renewal and healthy aging.
2.Supports cardiovascular health; long-term population data associate higher dietary spermidine intake with lower cardiovascular mortality.
3.Supports cognitive function and neuroprotection, helping to maintain memory and focus with age.
4.Supports immune function and a healthy inflammatory balance.
5.Supports hair growth and skin renewal; clinically studied in cosmeceutical applications (topical spermidine significantly increased the anagen, growth-phase hair-follicle ratio in a randomized controlled trial).
6.Supports mitochondrial function and overall metabolic health.
Application Fields
Recommended applications: dietary supplements (longevity, cellular-health and healthy-aging formulas; cognitive and cardiovascular support), functional foods & beverages, and cosmetics / nutricosmetics (hair-growth and skin-renewal products; typical cosmetic use 0.001%–0.5%).
Suggested dosage: finished oral products commonly deliver 1–3 mg of spermidine per day (clinical research has used approximately 1–6 mg/day). Formulate the wheat-germ extract accordingly - e.g., a 300 mg serving of 1% extract provides 3 mg of spermidine.
Comparison: Natural vs. Fermented vs. Synthetic
|
Comparison |
Natural (Wheat Germ Extract, Ours) |
Fermented / Biotech |
Chemically Synthesized |
|
Source |
Wheat germ (Triticum aestivum), food-grade botanical origin |
Engineered microbial fermentation |
Industrial chemical monomer synthesis |
|
Production route |
Water/ethanol extraction + physical purification |
Bioreactor fermentation |
Multi-step organic chemistry |
|
Label positioning |
"Natural", "Plant-Based", "Vegan", clean-label |
"Fermentation-derived" |
Cannot be labeled natural plant extract |
|
Co-active matrix |
Retains natural polyamines, B-vitamins, plant bioactives |
Single compound |
Single compound |
|
Residual risk |
Minimal; allergen (gluten) management applies |
Fermentation by-products |
Residual solvents / reagents |
|
Cost level |
Highest |
Moderate |
Lowest |
|
Best fit |
Premium clean-label longevity & anti-aging brands |
Mass-market supplements |
Cost-driven formulations |
Technical Specifications
|
Item |
Specification |
Method |
|
Product Name |
Natural Spermidine (Wheat Germ Extract) |
- |
|
CAS No. |
124-20-9 |
- |
|
Botanical Source |
Triticum aestivum (wheat germ) |
- |
|
Molecular Formula |
C7H19N3 |
- |
|
Molecular Weight |
145.25 g/mol |
- |
|
Standardized Content |
1.0% |
HPLC / GC |
|
Appearance |
Off-white to light-yellow fine powder |
Visual |
|
Extraction |
Water / ethanol, food-grade |
- |
|
Loss on Drying |
≤5.0% |
Gravimetric |
|
Heavy Metals |
≤10 ppm (total) |
ICP / AAS |
|
Total Plate Count |
≤1,000 cfu/g |
- |
|
Yeast & Mold |
≤100 cfu/g |
- |
|
Salmonella / E. coli |
Negative / Negative |
- |
|
Particle Size |
≥95% through 80 mesh |
Sieve |
|
Storage |
Sealed, cool & dry, protected from light & heat |
- |
|
Shelf Life |
24 months |
- |
Export Certificates
Facility certifications: HACCP / ISO 9001 / GMP / Halal
Documentation supplied with every order: batch COA, MSDS/SDS, TDS, allergen statement, GMO-free statement
Gluten status: wheat germ extract contains gluten. The extract can be processed to meet gluten-free specifications; allergen and gluten testing can be arranged for every batch.
Non-GMO statement supplied with every batch

Why choose us
With in-house production and a fully integrated supply chain, LANDNUTRA guarantees stable, pure and natural product quality for every batch. We source raw materials from certified farms, free of pesticides, heavy metals and fillers. Full-process documentation enables complete ingredient traceability to support your market compliance.
LANDNUTRA consistently invests in advanced technology and R&D to optimize product quality and innovation. Our robust supply chain ensures stable, on-time bulk delivery without delays. More than a raw material supplier, we serve as your reliable long-term strategic partner, dedicated to driving your brand and product success.
If Natural Spermidine Powder aligns with your product development plans, we welcome your enquiry. Our team is ready to provide samples, technical data sheets, and formulation support tailored to your specific needs.
Email: wangjing@landnutra.com
WhatsApp: +86 18092657549
FAQ
Q: What is autophagy and why is spermidine important?
A: Autophagy is the cell's natural cleanup and recycling process that removes damaged proteins and organelles. Spermidine is one of the best-studied natural regulators of autophagy, and endogenous spermidine levels decline with age - which is why dietary and supplemental sources become increasingly important.
Q: Is this product gluten-free?
A: The raw material is wheat germ. The extract can be processed to meet gluten-free specifications; full allergen-management details are available on request.
Q: Why choose wheat-germ-derived natural spermidine over synthetic?
A: The natural extract offers a traceable botanical origin, a clean-label "Natural / Plant-Based" story, and a full-spectrum matrix of co-active polyamines and plant bioactives that isolated synthetic spermidine cannot provide.
Q: What standardized strengths do you supply?
A: The standard strength is 1.0% (HPLC/GC).
Q: What is the typical dosage in finished products?
A: Most finished oral products deliver 1–3 mg of spermidine per day; clinical research has used approximately 1–6 mg/day.
Worldwide Delivery, Arranged for You
We deliver our ingredients to customers across global markets, choosing the most suitable shipping solution for every order and providing complete documentation along the way. Every delivery is handled end to end, with our team staying with the shipment until it reaches you.

Global Presence Through Industry Events
We regularly take part in international industry exhibitions to meet partners, share expertise and stay close to market trends. Details of our upcoming events are available on request.

Partnerships Built on Results
We work with brands and manufacturers across different markets and categories, supporting them from sample stage to commercial supply. Specific references and case details are shared directly with qualified customers upon request.

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