Urolithin A (CAS 1143-70-0) is a natural postbiotic metabolite formed when specific gut bacteria break down ellagitannins - polyphenols abundant in pomegranates. It is one of the most extensively studied natural molecules for cellular rejuvenation and healthy aging, and the most clinically validated natural activator of mitophagy - the cell's own quality-control process that recycles damaged mitochondria.
Our Natural Urolithin A is derived from ellagitannin-rich pomegranate sources through a nature-inspired metabolic conversion that mirrors the body's own gut-microbiome pathway - an alternative to engineered microbial fermentation and multi-step chemical synthesis.
Why this matters: research indicates that fewer than half of adults reliably produce meaningful amounts of urolithin A from food alone, and conversion capacity declines with age. Supplementing the pre-formed, bioidentical compound delivers a consistent, clinically relevant dose every time - independent of the consumer's microbiome.
Why Natural - The Natural Advantage
1.Follows nature's own blueprint. Urolithin A is the exact metabolite the human gut produces from pomegranate ellagitannins. Our natural route mirrors this endogenous metabolic logic instead of relying on engineered bioreactors or industrial chemistry.
2.Recognizable botanical sourcing. The starting material is ellagitannin-rich pomegranate biomass - not GMO-engineered microbial systems or petroleum-derived intermediates - enabling honest "Natural", "Plant-Derived" and "Clean Label" positioning.
3.Full traceability. From raw botanical origin through conversion and purification to the finished batch, every step is documented and verifiable via batch-level Certificates of Analysis.
4.Cleaner production profile. Food-grade, plant-origin processing with a minimal solvent footprint, compared with the heavier chemical processing typical of synthetic routes.
5.Distinct market positioning. In the fast-growing US/EU healthy-aging and sports-nutrition segments, brands are actively seeking natural, clean-label mitophagy ingredients; a genuine natural story supports a premium brand position at retail.
6.Naturally limited supply: urolithin A occurs at trace levels in its botanical sources and the natural route is demanding, so genuine natural material is scarce by definition - a rarity that adds to its value for premium formulations.
COA (Certificate of Analysis)
|
Item |
Specification |
Result |
Method |
|
Appearance |
White to pale-yellow crystalline powder |
Conforms |
Visual |
|
Identification |
Conforms to reference standard |
Conforms |
HPLC / IR |
|
Assay |
5.0% (standardized) |
7.3% |
HPLC |
|
Loss on Drying |
≤0.5% |
0.28% |
Gravimetric |
|
Heavy Metals (Total) |
≤10 ppm |
<5 ppm |
ICP / AAS |
|
Lead (Pb) |
≤3 mg/kg |
<1 ppm |
ICP-MS / AAS |
|
Arsenic (As) |
≤2 mg/kg |
<1 ppm |
ICP-MS / AAS |
|
Cadmium (Cd) |
≤1 mg/kg |
<0.5 ppm |
ICP-MS / AAS |
|
Mercury (Hg) |
≤0.1 mg/kg |
<0.05 ppm |
ICP-MS / AAS |
|
Residual Solvents |
Conforms |
Conforms |
GC |
|
Total Plate Count |
≤1,000 cfu/g |
<10 CFU/g |
Plate count |
|
Yeast & Mold |
≤100 cfu/g |
<10 CFU/g |
Plate count |
|
E. coli |
Negative |
Negative |
Plate count / PCR |
|
Salmonella |
Negative |
Negative |
Plate count / PCR |
|
Particle Size |
≥95% through 80 mesh |
98% through 80 mesh |
Sieve |
|
Storage / Shelf Life |
Sealed, cool & dry, protected from light; 24 months |
||
Product Benefits
1.Activates mitophagy - the selective cellular cleanup of damaged mitochondria - supporting mitochondrial quality, cellular energy production and healthy aging.
2.Supports muscle strength, endurance and physical performance in middle-aged and older adults, with evidence from randomized human trials (published four-month trials reported improvements in muscle strength of up to ~12% and gains in walking endurance).
3.Supports cellular energy metabolism and mitochondrial respiratory capacity in skeletal muscle.
4.Helps maintain a healthy inflammatory balance by supporting normal levels of inflammatory markers (IL-6, TNF-α, CRP) in clinical and preclinical studies.
5.Small lipophilic molecule (~228 Da) that is orally bioavailable and can cross the blood-brain barrier, supporting systemic cellular benefits.
6.Highly suited to healthy-aging, longevity, sports-nutrition and premium skincare formulations.
Product Quality Advantages
Standardized Assay Content: Urolithin A standardized to 5.0%, actual tested value reaches 7.3%, stable content for every batch.
Heavy Metals Strictly Locked Within Low Range: Tested via ICP-MS/AAS, Pb, As, Cd, Hg contents are far below specification limits.
Low Moisture & Good Stability: Loss on drying ≤0.5%, actual result 0.28%, reduces degradation risk during storage.
Strict Multi-Round Microbial Control: Every batch undergoes full microbiology testing; E.coli and Salmonella negative, low total plate count & yeast mold.
Uniform Particle Size: ≥95% pass through 80 mesh, actual 98% through 80 mesh, good powder flow for blending & encapsulation.
Long Shelf Life: Store in sealed, cool dry place away from light; 24 months shelf life under proper storage condition.
Application Fields
Recommended applications: dietary supplements (healthy-aging, longevity, mitochondrial & energy support, muscle health), sports nutrition (endurance, recovery, strength), functional foods & beverages, and premium cosmetics (topical cellular anti-aging).
Suggested dosage for finished products: 250–1,000 mg/day. Published human trials used 500–1,000 mg/day over 2–4 months; the final dose should be confirmed against the target market, claim and formulation.
Professional ODM/OEM Services
Your Brand, Powered by Natural Urolithin A - Backed by LANDNUTRA.
We provide full ODM/OEM manufacturing for finished products using Natural Urolithin A powder as the active ingredient - from concept to commercial delivery, all under one roof.
Capsules: 100 mg, 200 mg; vegetarian or gelatin; custom bottle/blister packaging.
Softgels: Lipid-based fill with microencapsulated ubiquinol; custom shapes and sizes available.
Powder Blends & Stick Packs: Single-serve sachets or multi-serving tubs; commonly paired with magnesium, B-vitamins, or collagen.
Functional Gummies & Chews: Pectin-based, sugar-free options with integrated flavouring and taste masking.
Specialised Delivery Formats: Liposomal ubiquinol dispersions, oil-based suspensions, and emulsified liquid shots.
Additional Services: Flavour masking, antioxidant synergy development, third-party certifications (Kosher, HALAL, NSF, Informed Sport), accelerated stability studies, and full regulatory documentation.
Contact: wangjing@landnutra.com | WhatsApp: +86 18092657549
Comparison: Natural vs. Fermented vs. Synthetic
|
Comparison |
Natural / Plant-Derived (Ours) |
Fermented / Bioconverted |
Chemically Synthesized |
|
Source |
Ellagitannin-rich pomegranate (botanical source) |
Engineered microbial fermentation / bioconversion of substrates |
Multi-step chemical synthesis from industrial intermediates |
|
Production route |
Nature-inspired metabolic conversion + purification, mirroring the human gut pathway |
Bioreactor fermentation, extraction, purification |
Chemical reactors, recrystallization |
|
Label positioning |
"Natural", "Plant-Derived", clean-label friendly |
"Fermentation-derived" (bio-identical molecule) |
Cannot be labeled natural |
|
Co-active matrix |
Retains plant-origin polyphenolic background |
Single purified compound |
Single purified compound |
|
Residual risk |
Minimal; food-grade extraction |
Fermentation by-products; potential allergen trace risk |
Residual solvents require strict COA control |
|
Cost level |
Highest |
Moderate |
Lowest |
|
Best fit |
Premium clean-label healthy-aging / sports-nutrition brands |
Mass-market supplements |
Cost-driven formulations |
Export Certificates
Facility certifications: HACCP / ISO 9001 / GMP / Halal
Documentation supplied with every order: batch COA, MSDS/SDS, TDS, allergen statement, GMO statement
Third-party testing: batch verification by SGS / Eurofins / Intertek
Non-GMO statement supplied with every batch
Email: wangjing@landnutra.com
WhatsApp: +86 18092657549
FAQ
Q: Is Natural Urolithin A the same as pomegranate extract?
A: No. Pomegranate contains ellagitannins - the precursors. Urolithin A is the bioactive metabolite the body forms from them (and only if the right gut bacteria are present). Our product provides the finished, pre-formed active compound directly, at a consistent, clinically relevant dose.
Q: Why choose the natural route over fermentation?
A: The natural route starts from recognizable botanical raw materials, follows the body's own metabolic pathway and supports clean-label "Natural / Plant-Derived" claims that fermented or synthetic grades cannot. It also carries a fully traceable, food-grade processing profile.
Q: What purity and documentation do you supply?
A: We supply 5% standardized material (HPLC-verified) as standard, with a batch COA, MSDS, TDS and applicable third-party test reports and certifications.
Q: Do you provide samples?
A: Yes - free samples are available for evaluation; please contact us with your formulation or application.
Q: What dosage is used in finished products?
A: Published human trials used 500–1,000 mg/day; most commercial formulas are designed in the 250–1,000 mg/day range depending on the market and claim.
Q: What is your MOQ and lead time?
A: MOQ is 1 kg for sampling, with bulk orders from 25 kg. Lead time is 7–15 days for stock items. Please contact us for a quotation.
Worldwide Delivery, Arranged for You
We deliver our ingredients to customers across global markets, choosing the most suitable shipping solution for every order and providing complete documentation along the way. Every delivery is handled end to end, with our team staying with the shipment until it reaches you.
Global Presence Through Industry Events
We regularly take part in international industry exhibitions to meet partners, share expertise and stay close to market trends. Details of our upcoming events are available on request.
Partnerships Built on Results
We work with brands and manufacturer partners across different markets and categories, supporting them from sample stage to commercial bulk supply. Specific references and case details are shared directly with qualified customers upon request.
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