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Citicoline Powder

Citicoline Powder

1. Specification： ≥ 98.0% – 99.0% (HPLC, on dried basis)
2. Sample： Sample Available
3. Test method： HPLC / UPLC / USP method
4. Synonyms： Citicoline, Cytidine diphosphate-choline, CDP-Choline, Cytidine 5'-diphosphocholine, Citicoline sodium (sodium salt form)
5. Appearance： White to off-white crystalline powder
6. Particle size： >95% pass 80 mesh
7. MOQ： 1 KG
8. Package： 1kg/foil bag, 25kgs/drum
9. Certificate： HACCP, ISO 22000, GMP, HALAL (available upon request)
10. Molecular Formula: C₁₄H₂₆N₄O₁₁P₂ (free acid); C₁₄H₂₅N₄NaO₁₁P₂ (sodium salt)
11. CAS number: 987-78-0 (free acid); 33818-15-4 (sodium salt)
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Description

 

Citicoline Powder

Citicoline, also known as CDP-Choline, is a naturally occurring compound and a highly bioavailable source of choline. It is an essential intermediate in the biosynthesis of phosphatidylcholine, a major phospholipid component of all cell membranes. As a dietary supplement, citicoline provides both choline and cytidine, two components that are rapidly absorbed in the intestine and cross the blood-brain barrier.

🧠 The "Membrane Builder" for Brain Health and Focus: Citicoline's primary mechanism of action is its role as a precursor to phosphatidylcholine, which is critical for maintaining the structural integrity and fluidity of neuronal cell membranes. By supporting membrane health, citicoline promotes efficient neurotransmission and protects neurons from damage.

Neuroprotective and Nootropic Properties: Citicoline exhibits neuroprotective activity by inhibiting the action of phospholipases, preventing excessive formation of free radicals, and reducing apoptosis. It increases levels of key neurotransmitters, including acetylcholine, dopamine, and norepinephrine, supporting memory, focus, and mental clarity.

Clinical Applications: Citicoline has been studied for its potential to support recovery in stroke patients, reduce memory loss associated with aging, and improve vision in patients with glaucoma. It is also used to support cognitive and behavioral disorders in degenerative and vascular brain diseases.

❄️ Storage Note: Citicoline is hygroscopic. Store in original sealed container under cool, dry conditions (≤25°C, ≤60% RH). For long-term storage, recommend 2–8°C or -20°C.

Specification: ≥98.0% – 99.0% (HPLC, on dried basis)
Sample: Sample Available
Test method: HPLC / UPLC / USP method
Synonyms: Citicoline, Cytidine diphosphate-choline, CDP-Choline, Cytidine 5'-diphosphocholine, Citicoline sodium
MOQ: 1 KG  |  Package: 1kg/foil bag, 25kgs/drum
Certificate: HACCP, ISO 22000, GMP, HALAL (available upon request)
Molecular Formula: C₁₄H₂₆N₄O₁₁P₂  |  CAS: 987-78-0

Citicoline Powder
Product Characteristics
 
🧂

Appearance

White to off-white crystalline powder; odorless.
⚗️

Purity

≥98% – 99% (HPLC) - high-purity nootropic.
💧

Solubility

Freely soluble in water - ideal for beverages.
🧬

Mechanism

Phosphatidylcholine precursor; membrane integrity support.
📏

Particle Size

>95% pass 80 mesh.
🏭

GMP Manufacturing

Fermentation‑derived with full traceability.

COA (Certificate of Analysis)

>

Benefits of Citicoline Powder

01Supports Memory & Cognitive Function

Citicoline increases levels of acetylcholine, dopamine, and norepinephrine, supporting memory, focus, and mental clarity. Research suggests it helps prevent memory impairment.

02Neuroprotection & Brain Cell Health

Promotes brain cell health and communication by protecting neuronal cell membranes and reducing oxidative stress. Inhibits phospholipases and prevents excessive free radical formation.

03Supports Recovery in Neurological Conditions

Studied for its potential to support recovery in stroke patients, reduce memory loss due to aging, and improve vision in glaucoma patients. Used in acute and recovery periods of ischemic and hemorrhagic strokes.

04Membrane Integrity & Phospholipid Synthesis

As an intermediate in the biosynthesis of phosphatidylcholine, citicoline is essential for maintaining the structural integrity and fluidity of all cell membranes.

05Phosphatidylcholine Precursor

Provides both choline and cytidine - two components that are rapidly absorbed and cross the blood-brain barrier for direct brain support.

06Multiple Forms Available

Offered as free acid (≥98.5%) and sodium salt forms - both bioavailable, with sodium salt offering enhanced stability and solubility.

Application Fields

Dietary Supplements (Hero Application): Memory & focus capsules & tablets (250–500 mg), nootropic & brain health blends, stress & sleep support, powdered drink mixes, gummies & chewables.
Clinical Nutrition & Pharmaceuticals: Neurological support formulas, medical foods for age‑related cognitive decline.
OEM Finished Products: Cognitive support capsules, brain health complex, focus powder sticks, memory & focus gummies, protein bars - full custom manufacturing available.

Production Process

Production process of Citicoline

Process: Fermentation (non‑GMO microorganisms) → ion‑exchange chromatography → crystallization → gentle drying → milling → sieving → packaging.

Product Quality Advantage

≥98% – 99% Purity – High-quality nootropic.

Neuroprotective – Supports brain cell health and membrane integrity.

Low Heavy Metals – Pb <2 ppm.

Excellent Solubility – Freely soluble in water.

Excipient‑Free – 100% active ingredient.

cGMP Certified – Full traceability and documentation.

Fermentation Facility
Quality Control Lab

Annual Capacity: 1,500 Tons | 15+ years of nootropic expertise

Professional ODM/OEM Services

We provide full OEM/ODM manufacturing for finished products using Citicoline as the active ingredient - from concept to commercial delivery, all under one roof.

① Finished Dosage Forms
Capsules: 250 mg, 500 mg, 750 mg; vegetarian/gelatin; custom bottle/blister.
Tablets: Direct compression; round/oval; debossing.
Chews & Gummies: Natural/artificial flavors; sugar‑free options.
Powder Blends: Stick packs, tubs; with Alpha-GPC, Bacopa, Phosphatidylserine.
Liquids: Solutions, ready‑to‑drink.
Bars: Protein bars, snack bars.

② Combination Options
Citicoline + Alpha-GPC (dual choline), Citicoline + Bacopa (cognitive synergy), Citicoline + Phosphatidylserine (membrane support).

③ Additional Services
Flavor development, third‑party certification (NSF, Informed Sport, Kosher, HALAL), stability testing, regulatory documentation.

📧 Email: wangjing@landnutra.com

📱 WhatsApp: +86 18092657549

All backed by LANDNUTRA's quality assurance - full GMP, Halal, Kosher, COA certification and complete traceability from sourcing to finished product.

Export Certificates

Certificates HACCP ISO GMP Halal

Why choose us

XI'AN LANDNUTRA CO., LTD. – Your Trusted Manufacturer of Functional Ingredients. Rooted in Quality, Driven by Expertise, Committed to Health and Excellence.

Strong Production Capability: Annual capacity 1,500 tons. 15+ years experience, own facility.
Leading Service: ONE-STOP OEM/ODM from pre-sales to after-sales.
Quality Assurance: CQC-certified enterprise, purity embedded in every process.
Broad Market: Botanical Extracts, Cosmetic Ingredients, Functional Ingredients.

15+ years of experience in functional ingredients and nootropic compounds. Vertically integrated from raw material sourcing to finished goods manufacturing. Batch‑specific COA including assay, heavy metals, loss on drying, and microbial limits. Technical support for formulation and stability.

FAQ

Q1: What is Citicoline, and how does it work?
A: Citicoline (CDP-Choline) is a highly bioavailable source of choline and cytidine. It is an essential intermediate in the synthesis of phosphatidylcholine, a major component of cell membranes. It supports memory, focus, and neuroprotection by increasing neurotransmitter levels and protecting neuronal cell membranes.
Q2: What is the difference between Citicoline and Citicoline Sodium?
A: Citicoline (free acid) is the non-salt form. Citicoline sodium is the sodium salt form, which offers enhanced stability and solubility. Both forms are bioavailable and effective. The sodium salt is more commonly used in commercial supplements.
Q3: What is the recommended daily dose?
A: Typical doses range from 250 mg to 1,000 mg per day, depending on the application. For general cognitive support, 250–500 mg per day is common. Always consult a healthcare provider for personalized recommendations.
Q4: Is Citicoline safe?
A: Citicoline is generally well-tolerated and has an excellent safety profile. It has been studied in clinical settings for stroke recovery and cognitive disorders. No significant adverse effects have been reported at recommended doses.
Q5: How is Citicoline different from Alpha-GPC or Choline Bitartrate?
A: Citicoline provides both choline and cytidine, supporting membrane synthesis and neurotransmitter production. Alpha-GPC is a choline precursor that also supports acetylcholine synthesis. Choline bitartrate is a simpler choline salt with lower bioavailability. Citicoline is often preferred for its dual mechanism and neuroprotective properties.
Q6: Is Citicoline vegan?
A: Yes. Our citicoline is produced via fermentation from non-animal sources. It does not contain any animal-derived components.
Q7: What is the shelf life?
A: 24 months in original sealed container under cool, dry conditions (≤25°C, ≤60% RH). For long-term storage, recommend 2–8°C or -20°C. Once opened, use within 12 months.
Q8: Can Citicoline be used in clear liquid supplements?
A: Yes. Citicoline is freely soluble in water, making it suitable for clear liquid formulations, ready-to-drink beverages, and powder mixes.
Q9: Can Citicoline be combined with other nootropics?
A: Yes - Citicoline is often combined with Alpha-GPC, Bacopa, Phosphatidylserine, and other cognitive-support ingredients for synergistic brain health formulations.
Q10: Is Citicoline suitable for gummies?
A: Yes - with proper formulation. Its neutral taste and high solubility make it suitable for gummies and chewable supplements.
Q11: What is the difference between Citicoline and CDP-Choline?
A: They are the same compound. Citicoline is the common name, while CDP-Choline (Cytidine Diphosphate-Choline) is the chemical name. Both refer to the same molecule.
Q12: Can Citicoline be used for stroke recovery?
A: Citicoline has been studied for its potential to support recovery in stroke patients. It is used in the acute and recovery periods of ischemic and hemorrhagic strokes. Always consult a healthcare provider for therapeutic applications.

 

Test Item Specification Test Result Conclusion
Appearance White to off-white powder Conforms Pass
Assay (HPLC) ≥98.0% 98.5% Pass
Loss on Drying ≤5.0% 3.6% Pass
Heavy Metals (as Pb) ≤5 ppm <2 ppm Pass
pH (1% solution) 6.0 – 7.5 6.8 Pass
Total Plate Count ≤1,000 CFU/g <100 CFU/g Pass
E. Coli / Salmonella Negative Negative Pass

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