Description

Dihydronicotinamide Riboside Powder

Dihydronicotinamide riboside (NRH) is the reduced form of nicotinamide riboside (NR) and represents a new generation of NAD+ precursors with significantly enhanced potency. It is chemically identical to NR but with a critical difference: the pyridinium ring is reduced to a 1,4-dihydropyridine structure, which fundamentally alters its cellular uptake and metabolism.

⚡ The "Next-Generation NAD+ Booster": NRH has emerged as one of the most potent NAD+ concentration-enhancing agents discovered to date. Studies demonstrate that NRH increases cellular NAD+ levels by 2.5 to 10-fold over control values within as little as 1 hour of administration - a performance that significantly surpasses that of NR and NMN at equivalent concentrations.

The Distinct Metabolic Pathway: Unlike NR, which requires specific kinases (Nrk1/Nrk2) for phosphorylation, NRH is phosphorylated by adenosine kinase (ADK) to form NMNH (dihydronicotinamide mononucleotide), which is then converted to NAD+. This alternative pathway allows NRH to bypass the degradation issues that limit the effectiveness of NR and NMN.

Unique Biodistribution: NRH can be detected in multiple tissues after oral administration, including liver, kidney, heart, muscle, and even brain. This broad tissue distribution is a significant advantage over other NAD+ precursors.

❄️ Storage Note: NRH is sensitive to oxygen, light, and acidic conditions. Store under inert gas (nitrogen or argon) in the original sealed container, protected from light, at 2–8°C (short-term) or -20°C (long-term).

Specification: ≥95.0% – 97.0% (HPLC, on dried basis)
Sample: Sample Available
Test method: HPLC / LC-MS / NMR
Synonyms: NRH, 1,4-Dihydronicotinamide riboside, Reduced nicotinamide riboside, Dihydronicotinamide riboside chloride
MOQ: 1 KG | Package: 1kg/foil bag (under inert gas, light-protected), 25kgs/drum
Certificate: HACCP, ISO 22000, GMP
Molecular Formula: C₁₁H₁₆N₂O₅ | CAS: 19132-12-8

Product Characteristics

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Appearance

White to off-white or slightly yellowish powder; odorless.

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Purity

≥95% – 97% (HPLC) - high-potency NAD+ precursor.

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Potency

2.5–10× NAD+ increase in 1 hour - surpasses NR and NMN.

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Pathway

ADK-dependent - bypasses Nrk1/Nrk2 limitations.

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Particle Size

>95% pass 80 mesh.

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GMP Manufacturing

Scalable synthesis with full traceability.

COA (Certificate of Analysis)

Benefits of Dihydronicotinamide Riboside Powder

01Superior NAD+ Enhancement

NRH is significantly more potent than NR and NMN at increasing cellular and tissue NAD+ levels. Acts within 1 hour of administration, providing rapid NAD+ elevation (2.5–10× increase).

02Unique ADK-Dependent Pathway

NRH is phosphorylated by adenosine kinase (ADK) to form NMNH, which is then converted to NAD+. This pathway bypasses the degradation issues that limit other NAD+ precursors.

03Metabolic Health Support

Chronic NRH administration improves glucose homeostasis, enhances pancreatic beta-cell function, increases muscle insulin sensitivity, reduces hepatic gluconeogenesis, and mobilizes fat deposition.

04Broad Tissue Distribution

NRH can be detected in multiple tissues after oral administration - liver, kidney, heart, muscle, and brain. Supports systemic NAD+ elevation.

05Neuroprotective Potential

NRH derivatives have demonstrated neuroprotective properties, protecting cells from oxidative stress and DNA damage. Can cross the blood-brain barrier.

06Next-Generation NAD+ Precursor

One of the most potent NAD+ concentration-enhancing agents discovered to date - a significant advancement beyond NR and NMN.

Application Fields

Dietary Supplements (Hero Application): Capsules & tablets (cellular energy & longevity), powdered drink mixes, gummies & chewables, multivitamin blends.
Research & Clinical Applications: NAD+ metabolism studies, metabolic disorder research (obesity, diabetes), neuroprotection studies.
OEM Finished Products: Cellular energy capsules, longevity stack (with NMN, resveratrol), NAD+ booster powder sticks, energy gummies - full custom manufacturing available.

Production Process

Production process of Dihydronicotinamide Riboside

Process: NRCl + sodium dithionate (reduction) → purification (column chromatography) → crystallization → gentle drying → milling → sieving → inert gas packaging.

Product Quality Advantage

≥95% – 97% Purity – High-potency NRH.

2.5–10× NAD+ Boost – Unmatched potency.

ADK-Dependent Pathway – Bypasses NR/NMN limitations.

Broad Tissue Distribution – Brain, liver, heart, muscle.

Low Heavy Metals – Pb <0.3 ppm.

cGMP Certified – Full traceability and documentation.

Annual Capacity: 1,500 Tons | 15+ years of NAD+ precursor expertise

Professional ODM/OEM Services

We provide full OEM/ODM manufacturing for finished products using Dihydronicotinamide Riboside as the active ingredient - from concept to commercial delivery, all under one roof.

① Finished Dosage Forms
Capsules: 100 mg, 150 mg, 200 mg; vegetarian/gelatin; custom bottle/blister.
Tablets: Direct compression; round/oval; debossing.
Chews & Gummies: Custom flavors, sugar‑free options.
Powder Blends: Stick packs, tubs; with NMN, resveratrol, pterostilbene.
Liquids: Solutions (requires stabilization).
Bars: Protein bars, snack bars.

② Combination Options
NRH + NMN (dual NAD+ pathway), NRH + Resveratrol (SIRT1 activation), NRH + Pterostilbene (longevity).

③ Additional Services
Flavor development, third‑party certification (NSF, Kosher, HALAL), stability testing (inert gas packaging), regulatory documentation.

📧 Email: wangjing@landnutra.com

📱 WhatsApp: +86 18092657549

All backed by LANDNUTRA's quality assurance - full GMP, Halal, Kosher, COA certification and complete traceability from sourcing to finished product.

Export Certificates

Certificates HACCP ISO GMP

Why choose us

XI'AN LANDNUTRA CO., LTD. – Your Trusted Manufacturer of Functional Ingredients. Rooted in Quality, Driven by Expertise, Committed to Health and Excellence.

Strong Production Capability: Annual capacity 1,500 tons. 15+ years experience, own facility.
Leading Service: ONE-STOP OEM/ODM from pre-sales to after-sales.
Quality Assurance: CQC-certified enterprise, purity embedded in every process.
Broad Market: Botanical Extracts, Cosmetic Ingredients, Functional Ingredients.

15+ years of experience in functional ingredients and NAD+ precursors. Vertically integrated from raw material sourcing to finished goods manufacturing. Batch‑specific COA including HPLC assay, LC-MS identification, heavy metals, and microbial limits. Technical support for formulation and stability.

FAQ

Q1: What is the difference between NRH and nicotinamide riboside (NR)?

A: NRH is the reduced form of NR. While NR is a pyridinium salt, NRH is a 1,4-dihydropyridine. This structural difference gives NRH a distinct metabolic pathway: it is phosphorylated by adenosine kinase (ADK), whereas NR requires Nrk1/Nrk2 kinases. NRH is also significantly more potent at increasing NAD+ levels.

Q2: What is the recommended dosage?

A: Research studies in mice have used doses ranging from 100 to 250 mg/kg body weight. For humans, typical NR doses are 250–500 mg per day; NRH is likely to be effective at lower doses due to its superior potency. Always consult a healthcare provider for personalized recommendations.

Q3: Is NRH safe?

A: NRH is well-tolerated at therapeutic doses. However, studies indicate that higher doses may reveal signs of toxicity, suggesting a narrower therapeutic window than other NAD+ precursors. It is recommended to use NRH at appropriate doses and under professional guidance.

Q4: How should NRH be stored?

A: NRH is sensitive to oxygen, light, and acidic conditions. Store in the original sealed container under inert gas (nitrogen or argon), protected from light, at 2–8°C for short-term storage or -20°C for long-term storage.

Q5: Is NRH stable in aqueous solution?

A: NRH is oxidized in the presence of oxygen and hydrolyzed quickly in acidic conditions. It is more stable under N₂ atmosphere, at lower temperatures, and under basic pH conditions. For liquid formulations, use with appropriate stabilizers and under inert gas.

Q6: Is NRH vegan?

A: Yes. NRH is synthesized from nicotinamide riboside chloride using chemical reduction. It does not contain any animal-derived components.

Q7: What is the shelf life?

A: 24 months when stored under inert gas at 2–8°C in the original sealed container, protected from light. Once opened, use within 6–12 months and keep container tightly sealed under inert gas.

Q8: Can NRH be combined with other NAD+ precursors?

A: Yes. NRH can be combined with other NAD+ precursors such as NMN or NR for synergistic effects. Our formulation experts can advise on optimal combinations.

Q9: Does NRH cross the blood-brain barrier?

A: Yes. NRH can be detected in brain tissue after oral administration, making it a promising candidate for neuroprotective applications.

Q10: What is the difference between NRH and NMNH?

A: NRH (dihydronicotinamide riboside) is the reduced form of NR. NMNH (dihydronicotinamide mononucleotide) is the phosphorylated intermediate formed when NRH is acted upon by adenosine kinase (ADK). NMNH is then converted to NAD+.

Q11: Can NRH be used in gummies?

A: Yes - with proper formulation and stability considerations. NRH is sensitive to oxygen and moisture, so protective measures are required. Our formulation team can advise on stability.

Q12: Is NRH suitable for clear liquid supplements?

A: NRH is soluble in water but is sensitive to oxygen and acidic conditions. Clear liquid formulations require strict inert gas protection, appropriate pH (basic), and stabilizers to prevent degradation.

Test Item	Specification (≥95% Grade)	Test Result	Conclusion
Appearance	White to off-white or slightly yellowish powder	Conforms	Pass
Assay (HPLC)	≥95.0%	96.2%	Pass
Identification (LC-MS)	Matches reference standard	Conforms	Pass
Water Content (KF)	≤2.0%	0.8%	Pass
Lead (Pb)	≤1 ppm	<0.3 ppm	Pass
Total Plate Count	≤1,000 CFU/g	<100 CFU/g	Pass
E. Coli / Salmonella	Negative	Negative	Pass

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